Evidence map›Paper›PMID 34575840›Full record

ReviewInternational journal of molecular sciences2021

Novel Strategies for Nanoparticle-Based Radiosensitization in Glioblastoma.

Henry Ruiz-Garcia, Cristopher Ramirez-Loera, Timothy D Malouff, Danushka S Seneviratne, Joshua D Palmer, Daniel M Trifiletti

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Nano-Based Technology in Glioblastoma.Molecules (Basel, Switzerland) · 2025
    Review
  7. State-of-the-art application of nanoparticles in radiotherapy: a platform for synergistic effects in cancer treatment.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025
    Review
  8. Review
  9. Article
  10. Magnetic Hyperthermia in Glioblastoma Multiforme Treatment.International journal of molecular sciences · 2024
    Review
  11. Current approaches in glioblastoma multiforme immunotherapy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Review
  12. Nanoparticle-Based Treatment in Glioblastoma.Journal of personalized medicine · 2023
    Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Iodine Nanoparticles (NiodxPharmaceutics · 2022
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Henry Ruiz-GarciaDepartment of Radiation Oncology, Mayo Clinic, Jacksonville, FL 32224, USA.
Cristopher Ramirez-LoeraDepartment of Neurological Surgery, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-0248-2739
Timothy D MalouffDepartment of Radiation Oncology, Mayo Clinic, Jacksonville, FL 32224, USA.
Danushka S SeneviratneDepartment of Radiation Oncology, Mayo Clinic, Jacksonville, FL 32224, USA.
Joshua D PalmerDepartment of Radiation Oncology, Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0003-3311-0129
Daniel M TrifilettiDepartment of Radiation Oncology, Mayo Clinic, Jacksonville, FL 32224, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiotherapy (RT) is one of the cornerstones in the current treatment paradigm for glioblastoma (GBM). However, little has changed in the management of GBM since the establishment of the current protocol in 2005, and the prognosis remains grim. Radioresistance is one of the hallmarks for treatment failure, and different therapeutic strategies are aimed at overcoming it. Among these strategies, nanomedicine has advantages over conventional tumor therapeutics, including improvements in drug delivery and enhanced antitumor properties. Radiosensitizing strategies using nanoparticles (NP) are actively under study and hold promise to improve the treatment response. We aim to describe the basis of nanomedicine for GBM treatment, current evidence in radiosensitization efforts using nanoparticles, and novel strategies, such as preoperative radiation, that could be synergized with nanoradiosensitizers.

Indexed as

NanomedicineNanoparticlesNanotechnologyAnimalsBrain NeoplasmsDrug CarriersDrug Delivery SystemsGlioblastomaHumansModels, AnimalRadiation-Sensitizing AgentsStem CellsDrug CarriersRadiation-Sensitizing Agentsglioblastomananoparticleradiosensitizationradiotherapystem-cellstheranostic

Identifiers

PMID34575840
PMCPMC8465220

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.