Evidence map›Paper›PMID 34575831›Full record

ReviewInternational journal of molecular sciences2021

Lipid Nanoparticle Technology for Delivering Biologically Active Fatty Acids and Monoglycerides.

Jia Ying Brenda Tan, Bo Kyeong Yoon, Nam-Joon Cho, Jasmina Lovrić, Mario Jug, Joshua A Jackman

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Jia Ying Brenda TanSchool of Chemical Engineering and Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon 16419, Korea.
Bo Kyeong YoonSchool of Chemical Engineering and Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon 16419, Korea.
Nam-Joon ChoSchool of Materials Science and Engineering, Nanyang Technological University, Singapore 637553, Singapore.ORCID 0000-0002-8692-8955
Jasmina LovrićDepartment of Pharmaceutical Technology, Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, Croatia.
Mario JugDepartment of Pharmaceutical Technology, Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, Croatia.
Joshua A JackmanSchool of Chemical Engineering and Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon 16419, Korea.ORCID 0000-0002-1800-8102
Nanyang Technological University · SGUniversity of Zagreb · HRChonnam National University · KRSungkyunkwan University · KR

Funding

National Research Foundation of Korea 2019H1D3A1A01070318National Research Foundation of Korea 2020K1A3A1A39112724
6 · The paper itself

Abstract

There is enormous interest in utilizing biologically active fatty acids and monoglycerides to treat phospholipid membrane-related medical diseases, especially with the global health importance of membrane-enveloped viruses and bacteria. However, it is difficult to practically deliver lipophilic fatty acids and monoglycerides for therapeutic applications, which has led to the emergence of lipid nanoparticle platforms that support molecular encapsulation and functional presentation. Herein, we introduce various classes of lipid nanoparticle technology and critically examine the latest progress in utilizing lipid nanoparticles to deliver fatty acids and monoglycerides in order to treat medical diseases related to infectious pathogens, cancer, and inflammation. Particular emphasis is placed on understanding how nanoparticle structure is related to biological function in terms of mechanism, potency, selectivity, and targeting. We also discuss translational opportunities and regulatory needs for utilizing lipid nanoparticles to deliver fatty acids and monoglycerides, including unmet clinical opportunities.

Indexed as

Drug CarriersDrug Delivery SystemsNanotechnologyChemical PhenomenaFatty AcidsHumansLipidsLiposomesMicellesMonoglyceridesNanocapsulesNanoparticlesDrug CarriersFatty AcidsLipidsLiposomesMicellesMonoglyceridesNanocapsulesbicellefatty acidlipid nanocapsulelipid nanoparticleliposomemonoglyceridenanoemulsionnanostructured lipid carrierpolymeric micellesolid lipid nanoparticle

Identifiers

PMID34575831
PMCPMC8465605
OpenAlexW3196453074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.