Evidence map›Paper›PMID 34575768›Full record

ArticleJournal of fungi (Basel, Switzerland)2021

Noninvasive Combined Diagnosis and Monitoring of

Radim Dobiáš, Anton Škríba, Tomáš Pluháček, Miloš Petřík, Andrea Palyzová, Marcela Káňová, Eva Čubová, Jiří Houšť, Jiří Novák, David A Stevens and 4 more

Registry-linked trialOpen access · goldAbstract readCase Reports
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05860387 (Early Diagnosis of Invasive Lung Aspergillosis), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05860387 recruitingnot on this mapstarted 2023, after this paper: background citation

Early Diagnosis of Invasive Lung Aspergillosis

TypeobservationalSponsorUniversity Hospital OstravaRan2023 to 2026Enrolled150ConditionsRespiratory Infection, Invasive Pulmonary AspergillosisArmsNext generation improvement of early invasive aspergillosis
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Effects of CFTR Modulators onInfectious disease reports · 2025
    Review
  2. Considerations for the use of inhaled antibiotics forBMJ open respiratory research · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Current and Future Pathways inAntibiotics (Basel, Switzerland) · 2023
    Review
  7. Diagnosis of Aspergillosis in Horses.Journal of fungi (Basel, Switzerland) · 2023
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Radim DobiášDepartment of Bacteriology and Mycology, Public Health Institute in Ostrava, 702 00 Ostrava, Czech Republic.ORCID 0000-0003-4299-9169
Anton ŠkríbaInstitute of Microbiology of the Czech Academy of Sciences, 142 20 Prague, Czech Republic.ORCID 0000-0003-1122-1098
Tomáš PluháčekInstitute of Microbiology of the Czech Academy of Sciences, 142 20 Prague, Czech Republic.ORCID 0000-0002-7417-0016
Miloš PetříkInstitute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, 779 00 Olomouc, Czech Republic.ORCID 0000-0003-1334-5916
Andrea PalyzováInstitute of Microbiology of the Czech Academy of Sciences, 142 20 Prague, Czech Republic.
Marcela KáňováDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Ostrava, 708 00 Ostrava, Czech Republic.
Eva ČubováDepartment of Internal Medicine, Ostrava City Hospital, 728 80 Ostrava, Czech Republic.
Jiří HoušťInstitute of Microbiology of the Czech Academy of Sciences, 142 20 Prague, Czech Republic.ORCID 0000-0002-3754-6539
Jiří NovákInstitute of Microbiology of the Czech Academy of Sciences, 142 20 Prague, Czech Republic.
David A StevensInfectious Disease Research Laboratory, California Institute for Medical Research, San Jose, CA 95128, USA.
Goran MitulovičClinical Department of Laboratory Medicine Proteomics Core Facility, Medical University of Vienna, A-1090 Wien, Austria.
Eva KrejčíDepartment of Bacteriology and Mycology, Public Health Institute in Ostrava, 702 00 Ostrava, Czech Republic.
Petr HubáčekDepartment of Medical Microbiology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, 150 06 Prague, Czech Republic.
Vladimír HavlíčekInstitute of Microbiology of the Czech Academy of Sciences, 142 20 Prague, Czech Republic.ORCID 0000-0002-8614-7059
Czech Academy of Sciences · CZUniversity of Ostrava · CZCalifornia Institute for Medical Research · USCharles University · CZInstitute of Molecular and Translational Medicine · CZMedical University of Vienna · ATUniversity Hospital Ostrava · CZ

Funding

Grantová Agentura České Republiky 19-10907SPalacky University IGA_PrF_2021_021
6 · The paper itself

Abstract

In acutely ill patients, particularly in intensive care units or in mixed infections, time to a microbe-specific diagnosis is critical to a successful outcome of therapy. We report the application of evolving technologies involving mass spectrometry to diagnose and monitor a patient's course. As proof of this concept, we studied five patients and used two rat models of mono-infection and coinfection. We report the noninvasive combined monitoring of

Indexed as

Aspergillus fumigatuscoinfectioninvasive infectionnoninvasive diagnosisPseudomonas aeruginosaquorum-sensing moleculessiderophoresvirulence factor

Identifiers

PMID34575768
PMCPMC8471143
OpenAlexW3197745131

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.