Evidence map›Paper›PMID 34575716›Full record

ArticleJournal of personalized medicine2021

Predictors of the CD24/CD11b Biomarker among Healthy Subjects.

Shiran Shapira, Gal Aiger, Amitay Ohayon, Dina Kazanov, Fatin Mdah, Marina Ben Shimon, Mori Hay-Levy, Lian Banon, Ido Laskov, Jacob Mashiah and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. CD24 in Head and Neck Malignancies-An Uprising Biomarker?Journal of personalized medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Shiran ShapiraIntegrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, Israel.
Gal AigerIntegrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, Israel.
Amitay OhayonIntegrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, Israel.
Dina KazanovIntegrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, Israel.
Fatin MdahIntegrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, Israel.
Marina Ben ShimonIntegrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, Israel.
Mori Hay-LevyIntegrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, Israel.
Lian BanonTel Aviv Medical Center, The Gastroenterology Institute, Tel Aviv 6423906, Israel.
Ido LaskovGynecologic Oncology Unit, Tel Aviv Medical Center, Tel Aviv 6423906, Israel.
Jacob MashiahSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6423906, Israel.
Shahar Lev-AriIntegrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, Israel.ORCID 0000-0003-0187-9427
Nadir ArberIntegrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, Israel.
Tel Aviv University · ILTel Aviv Sourasky Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The CD24 gene has raised considerable interest in tumor biology as a new prognostic factor and a biomarker for the early detection of cancer. There are currently no studies that assess predictors of CD24 in blood tests among healthy individuals. Our aims were (1) to evaluate predictors of the CD24/CD11b biomarker among healthy subjects and (2) to assess CD24/CD11b levels of participants with and without benign tumors. Our cohort included 1640 healthy subjects, aged 20-85, recruited at the Health Promotion and Integrated Cancer Prevention Center (ICPC) in the Tel Aviv Medical Center. Eligible subjects completed a detailed questionnaire on medical history and other epidemiologic information. CD24/CD11b expression in peripheral blood leukocytes (PBLs) obtained from blood samples of participants was analyzed by flow cytometry. Our results showed that the average levels of CD24/CD11b in healthy patients (22.8 ± 9.3) was statistically significant lower compared to subjects with benign cancers (26.1 ± 10.5,

Indexed as

biomarkerCD24preventionscreening test

Identifiers

PMID34575716
PMCPMC8471999
OpenAlexW3201263011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.