Evidence map›Paper›PMID 34575681›Full record

ReviewJournal of personalized medicine2021

Current Challenges in Deciphering Sutton Nevi-Literature Review and Personal Experience.

Roxana Nedelcu, Alexandra Dobre, Alice Brinzea, Ionela Hulea, Razvan Andrei, Sabina Zurac, Mihaela Balaban, Mihaela Antohe, Lorena Manea, Andreea Calinescu and 8 more

Abstract readReview
In one paragraph

Review in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. PD-L1Frontiers in immunology · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Unintended outcomes: Double halo nevus and vitiligo following laser therapy.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Roxana NedelcuGeneral Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Alexandra DobreGeneral Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0000-0001-6052-9027
Alice BrinzeaGeneral Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Ionela HuleaGeneral Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Razvan AndreiDepartment of Pathology and Dermatovenerology, Colentina Clinical Hospital, 020125 Bucharest, Romania.
Sabina ZuracGeneral Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Mihaela BalabanDerma 360 Clinic, 11273 Bucharest, Romania.
Mihaela AntoheGeneral Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Lorena ManeaGeneral Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Andreea CalinescuGeneral Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Anastasia ComanGeneral Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0000-0002-4575-2252
Florentina PantelimonDerma 360 Clinic, 11273 Bucharest, Romania.
Adina DobritoiuDerma 360 Clinic, 11273 Bucharest, Romania.
Catalin PopescuGeneral Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Raluca PopescuGeneral Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Elena BalasescuGeneral Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Daniela IonGeneral Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Gabriela TurcuGeneral Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0000-0001-5104-6066

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Halo nevi, known as leukoderma acquisitum centrifugum, Sutton nevus, leukopigmentary nevus, perinevoid vitiligo, or perinevoid leukoderma, together with vitiligo and melanoma-associated hypopigmentation, belong to the group of dermatoses designated as immunological leukodermas. The etiology and pathogenesis of halo nevi has not been fully elucidated. There are several mechanisms through which a lymphocytic infiltrate can induce tumoral regression. In this review, we aimed to update the knowledge about Sutton nevi starting with the clinical appearance and dermoscopic features, continuing with information regarding conventional microscopy, immunohistochemistry, and the immunological mechanisms responsible for the occurrence of halo nevi. We also included in the article original unpublished results when discussing dermoscopic, pathologic and immunohistochemical results in halo nevi. Sutton nevi are valuable models for studying antitumor reactions that the human body can generate. The slow and effective mechanism against a melanocytic skin tumor can teach us important lessons about both autoimmune diseases and anticancer defenses.

Indexed as

halo neviimmune responseinflammationskin tumorSutton nevi

Identifiers

PMID34575681
PMCPMC8470687

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.