Evidence map›Paper›PMID 34575612›Full record

ArticleJournal of personalized medicine2021

Molecular Prognostic Factors for Distant Metastases in Premenopausal Patients with HR+/HER2- Early Breast Cancer.

Hua Ni, Jörg Kumbrink, Doris Mayr, Alina Seiler, Friederike Hagemann, Tom Degenhardt, Sabine Sagebiel, Rachel Würstlein, Ronald Kates, Nadia Harbeck and 1 more

Abstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Identification of a gene expression signature associated with brain metastasis in colorectal cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Article
  3. The biology of SCUBE.Journal of biomedical science · 2023
    Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hua NiBreast Center, Department of Gynecology and Obstetrics and Comprehensive Cancer Center (CCC)-Munich, LMU University Hospital, 80337 Munich, Germany.
Jörg KumbrinkFaculty of Medicine, Institute of Pathology, Ludwig-Maximilians-University of Munich (LMU), 80337 Munich, Germany.
Doris MayrFaculty of Medicine, Institute of Pathology, Ludwig-Maximilians-University of Munich (LMU), 80337 Munich, Germany.
Alina SeilerBreast Center, Department of Gynecology and Obstetrics and Comprehensive Cancer Center (CCC)-Munich, LMU University Hospital, 80337 Munich, Germany.
Friederike HagemannBreast Center, Department of Gynecology and Obstetrics and Comprehensive Cancer Center (CCC)-Munich, LMU University Hospital, 80337 Munich, Germany.
Tom DegenhardtBreast Center, Department of Gynecology and Obstetrics and Comprehensive Cancer Center (CCC)-Munich, LMU University Hospital, 80337 Munich, Germany.
Sabine SagebielFaculty of Medicine, Institute of Pathology, Ludwig-Maximilians-University of Munich (LMU), 80337 Munich, Germany.
Rachel WürstleinBreast Center, Department of Gynecology and Obstetrics and Comprehensive Cancer Center (CCC)-Munich, LMU University Hospital, 80337 Munich, Germany.
Ronald KatesREK Consulting, 83624 Otterfing, Germany.
Nadia HarbeckBreast Center, Department of Gynecology and Obstetrics and Comprehensive Cancer Center (CCC)-Munich, LMU University Hospital, 80337 Munich, Germany.ORCID 0000-0002-9744-7372
Tanja K EggersmannBreast Center, Department of Gynecology and Obstetrics and Comprehensive Cancer Center (CCC)-Munich, LMU University Hospital, 80337 Munich, Germany.ORCID 0000-0003-3567-0576

Funding

China Scholarship Council 201806010411
6 · The paper itself

Abstract

Molecular factors that drive metastasis in premenopausal patients with hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-), early breast cancer (EBC) are largely unknown. To identify markers/signatures contributing to metastasis, we analyzed molecular changes in tumors from premenopausal patients who developed metastasis (M1) and who did not (M0). Ninety-seven premenopausal patients with HR+/HER2- EBC were included (M1,

Indexed as

breast cancerdistant metastasisexpression signature testsHER2 negativehormonal receptor positivemolecular markersmTORC1premenopausalprognostic factorsROR

Identifiers

PMID34575612
PMCPMC8468490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.