Evidence map›Paper›PMID 34575578›Full record

ArticlePharmaceutics2021

Comparative In Vitro Evaluation of Commercial Periodontal Gels on Antibacterial, Biocompatibility and Wound Healing Ability.

Marta Munar-Bestard, Maria Antonia Llopis-Grimalt, Joana Maria Ramis, Marta Monjo

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

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  5. ACS pharmacology & translational science · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Marta Munar-BestardCell Therapy and Tissue Engineering Group, Department of Fundamental Biology and Health Sciences, Research Institute on Health Sciences (IUNICS), University of the Balearic Islands, Ctra Valldemossa km 7.5, 07122 Palma, Spain.ORCID 0000-0002-9035-1335
Maria Antonia Llopis-GrimaltCell Therapy and Tissue Engineering Group, Department of Fundamental Biology and Health Sciences, Research Institute on Health Sciences (IUNICS), University of the Balearic Islands, Ctra Valldemossa km 7.5, 07122 Palma, Spain.ORCID 0000-0001-9924-0810
Joana Maria RamisCell Therapy and Tissue Engineering Group, Department of Fundamental Biology and Health Sciences, Research Institute on Health Sciences (IUNICS), University of the Balearic Islands, Ctra Valldemossa km 7.5, 07122 Palma, Spain.ORCID 0000-0001-9109-8362
Marta MonjoCell Therapy and Tissue Engineering Group, Department of Fundamental Biology and Health Sciences, Research Institute on Health Sciences (IUNICS), University of the Balearic Islands, Ctra Valldemossa km 7.5, 07122 Palma, Spain.ORCID 0000-0002-2731-9527
Health Research Institute of the Balearic Islands · ES

Funding

Direcció General d'Innovació i Recerca del Govern de les Illes Balears (PROCOE15/2017)ERDF European Regional Development Fund, (Fondos FEDER) (PROCOE15/2017)ESF European Social Fund and the ERDF European Regional Development Fund MS16/00124 and FI18/00104Fundació Universitat-Empresa de les Illes Balears PERIOGEL, Proof of concept call 2019Instituto de Salud Carlos III FI18/00104Instituto de Salud Carlos III MS16/00124Ministerio de Economía y Competividad MS16/00124 and FI18/00104Ministerio de Educación Cultura y Deporte FPU15/03412
6 · The paper itself

Abstract

In the last years, several studies testing commercial periodontal gels that contain chlorhexidine (CHX) or other antibacterial agents, have raised concerns regarding their cytotoxicity in periodontal tissues. We aimed at comparing the biocompatibility but also the efficacy as regards to the antibacterial and wound healing ability of different commercial periodontal gels. In vitro human gingival fibroblasts (GF) and a 3D model of human tissue equivalents of gingiva (GTE) were used under inflammatory conditions to evaluate wound closure, cytotoxicity and gene expression. Antibacterial effects were also investigated on

Indexed as

antibacterial activitychlorhexidineemdogainengineered 3D gingival tissuegingipain acitivitygingival fibroblastperiodontal gelPorphyromonas gingivalisregeneration

Identifiers

PMID34575578
PMCPMC8465455
OpenAlexW3199819840

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.