Evidence map›Paper›PMID 34575571›Full record

ArticlePharmaceutics2021

Microfluidic Technology for the Production of Hybrid Nanomedicines.

Ilaria Ottonelli, Jason Thomas Duskey, Arianna Rinaldi, Maria Vittoria Grazioli, Irene Parmeggiani, Maria Angela Vandelli, Leon Z Wang, Robert K Prud'homme, Giovanni Tosi, Barbara Ruozi

Abstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Development ofBeilstein journal of nanotechnology · 2026
    Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ilaria OttonelliNanotech Lab, Te. Far.T.I., Department Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0002-2135-2422
Jason Thomas DuskeyNanotech Lab, Te. Far.T.I., Department Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0003-2204-1981
Arianna RinaldiNanotech Lab, Te. Far.T.I., Department Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Maria Vittoria GrazioliNanotech Lab, Te. Far.T.I., Department Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Irene ParmeggianiNanotech Lab, Te. Far.T.I., Department Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Maria Angela VandelliNanotech Lab, Te. Far.T.I., Department Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Leon Z WangDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA.
Robert K Prud'hommeDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA.
Giovanni TosiNanotech Lab, Te. Far.T.I., Department Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0001-8318-667X
Barbara RuoziNanotech Lab, Te. Far.T.I., Department Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0002-2400-9910

Funding

IMI EU Grants Investigating Mechanisms and Models predictive of accessibility of therapeutics (IM2PACT) Into the Brain IMI2 - Call 12, GA n.807015(im2pact.org);Ministero degli Affari Esteri e della Cooperazione Internazionale MAE00691612020-06-26PorFesr Grant European Funding for the Regional Development):"MAT2REP: Biomateriali multifunzionali per l'autoriparazione di tessuti e organi" (2019-2021)
6 · The paper itself

Abstract

Microfluidic technologies have recently been applied as innovative methods for the production of a variety of nanomedicines (NMeds), demonstrating their potential on a global scale. The capacity to precisely control variables, such as the flow rate ratio, temperature, total flow rate, etc., allows for greater tunability of the NMed systems that are more standardized and automated than the ones obtained by well-known benchtop protocols. However, it is a crucial aspect to be able to obtain NMeds with the same characteristics of the previously optimized ones. In this study, we focused on the transfer of a production protocol for hybrid NMeds (H-NMeds) consisting of PLGA, Cholesterol, and Pluronic

Indexed as

hybrid nanoparticlesmicrofluidicsnanomedicinenanoprecipitation

Identifiers

PMID34575571
PMCPMC8465086

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.