Evidence map›Paper›PMID 34575552›Full record

ArticlePharmaceutics2021

Clay Nanotube Immobilization on Animal Hair for Sustained Anti-Lice Protection.

Naureen Rahman, Faith Hannah Scott, Yuri Lvov, Anna Stavitskaya, Farida Akhatova, Svetlana Konnova, Gӧlnur Fakhrullina, Rawil Fakhrullin

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Molecules (Basel, Switzerland) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Naureen RahmanInstitute for Micromanufacturing and Biomedical Engineering Program, Louisiana Tech University, Ruston, LA 71272, USA.
Faith Hannah ScottInstitute for Micromanufacturing and Biomedical Engineering Program, Louisiana Tech University, Ruston, LA 71272, USA.
Yuri LvovInstitute for Micromanufacturing and Biomedical Engineering Program, Louisiana Tech University, Ruston, LA 71272, USA.ORCID 0000-0003-0722-5643
Anna StavitskayaDepartment of Physical and Colloid Chemistry, Gubkin University, Leninsky Pr. 65, 119991 Moscow, Russia.ORCID 0000-0001-6094-7405
Farida AkhatovaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kreml urami 18, 420008 Kazan, Republic of Tatarstan, Russia.
Svetlana KonnovaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kreml urami 18, 420008 Kazan, Republic of Tatarstan, Russia.
Gӧlnur FakhrullinaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kreml urami 18, 420008 Kazan, Republic of Tatarstan, Russia.
Rawil FakhrullinInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kreml urami 18, 420008 Kazan, Republic of Tatarstan, Russia.ORCID 0000-0003-2015-7649
Kazan Federal University · RULouisiana Tech University · USGubkin Russian State University of Oil and Gas · RU

Funding

Russian Science Foundation 20-13-00247
6 · The paper itself

Abstract

Topical administration of drugs is required for the treatment of parasitic diseases and insect infestations; therefore, fabrication of nanoscale drug carriers for effective insecticide topical delivery is needed. Here we report the enhanced immobilization of halloysite tubule nanoclay onto semiaquatic capybaras which have hydrophobic hair surfaces as compared to their close relatives, land-dwelling guinea pigs, and other agricultural livestock. The hair surface of mammals varies in hydrophobicity having a cortex surrounded by cuticles. Spontaneous 1-2 µm thick halloysite hair coverages on the semi-aquatic rodent capybara, non-aquatic rodent guinea pig, and farm goats were compared. The best coating was found for capybara due to the elevated 5 wt% wax content. As a result, we suggest hair pretreatment with diluted wax for enhanced nanoclay adsorption. The formation of a stable goat hair coverage with a 2-3 µm halloysite layer loaded with permethrin insecticide allowed for long-lasting anti-parasitic protection, enduring multiple rain wettings and washings. We expect that our technology will find applications in animal parasitosis protection and may be extended to prolonged human anti-lice treatment.

Indexed as

antiparasitic formulationscapybaraguinea pighair surface engineeringhalloysiteself-assemblytopical drug administration

Identifiers

PMID34575552
PMCPMC8466176
OpenAlexW3200141687

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.