Evidence map›Paper›PMID 34575538›Full record

ReviewPharmaceutics2021

Licia Uccelli, Alessandra Boschi, Corrado Cittanti, Petra Martini, Stefano Panareo, Eugenia Tonini, Alberto Nieri, Luca Urso, Matteo Caracciolo, Luca Lodi and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Molecular radiotherapy for adult type metastatic neuroendocrine tumours in children.European journal of nuclear medicine and molecular imaging · 2025
    Observational
  7. Article
  8. Review
  9. EJNMMI radiopharmacy and chemistry · 2024
    Review
  10. Article
  11. Review
  12. Review
  13. Tumor-Targeted Interleukin 2 Boosts the Anticancer Activity of FAP-Directed Radioligand Therapeutics.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  14. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  15. Review
  16. Validation ofEJNMMI physics · 2023
    Article
  17. LutatheraPharmaceutics · 2023
    Review
  18. Pharmaceutics · 2023
    Review
  19. Relevance of Volumetric Parameters Applied to [Diagnostics (Basel, Switzerland) · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Licia UccelliDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-1490-0718
Alessandra BoschiDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-6382-1944
Corrado CittantiDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-5117-804X
Petra MartiniDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-4059-4814
Stefano PanareoNuclear Medicine Unit, University Hospital, 44124 Ferrara, Italy.
Eugenia ToniniMedical Physics Unit, University Hospital, 44124 Ferrara, Italy.
Alberto NieriNuclear Medicine Unit, University Hospital, 44124 Ferrara, Italy.
Luca UrsoNuclear Medicine Unit, University Hospital, 44124 Ferrara, Italy.ORCID 0000-0002-3007-3898
Matteo CaraccioloNuclear Medicine Unit, University Hospital, 44124 Ferrara, Italy.ORCID 0000-0003-4129-8328
Luca LodiNuclear Medicine Unit, University Hospital, 44124 Ferrara, Italy.
Aldo CarnevaleDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0001-8191-6042
Melchiore GigantiDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-5319-8685
Mirco BartolomeiNuclear Medicine Unit, University Hospital, 44124 Ferrara, Italy.
University of Ferrara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The PRRT (Peptide Receptor Radionuclide Therapy) is a promising modality treatment for patients with inoperable or metastatic neuroendocrine tumors (NETs). Progression-free survival (PFS) and overall survival (OS) of these patients are favorably comparable with standard therapies. The protagonist in this type of therapy is a somatostatin-modified peptide fragment ([Tyr3] octreotide), equipped with a specific chelating system (DOTA) capable of creating a stable bond with β-emitting radionuclides, such as yttrium-90 and lutetium-177. In this review, covering twenty five years of literature, we describe the characteristics and performances of the two most used therapeutic radiopharmaceuticals for the NETs radio-treatment: [

Indexed as

[177Lu]Lu-DOTATOC[90Y]Y-DOTATOCneuroendocrine tumorsPRRT

Identifiers

PMID34575538
PMCPMC8469896
OpenAlexW3199266799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.