Evidence map›Paper›PMID 34575511›Full record

ReviewPharmaceutics2021

Peptide-Conjugated Nano Delivery Systems for Therapy and Diagnosis of Cancer.

Isha Gaurav, Xuehan Wang, Abhimanyu Thakur, Ashok Iyaswamy, Sudha Thakur, Xiaoyu Chen, Gaurav Kumar, Min Li, Zhijun Yang

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Isha GauravSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Xuehan WangSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Abhimanyu ThakurCentre for Regenerative Medicine and Health, Hong Kong Institute of Science and Innovation-CAS Limited, Hong Kong, China.
Ashok IyaswamySchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.ORCID 0000-0003-0186-3863
Sudha ThakurNational Institute for Locomotor Disabilities (Divyangjan), Kolkata 700090, India.
Xiaoyu ChenSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Gaurav KumarSchool of Basic and Applied Science, Galgotias University, Greater Noida 203201, India.ORCID 0000-0003-2823-8419
Min LiSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Zhijun YangSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.ORCID 0000-0002-6094-0438

Funding

Innovation and Technology Fund (ITF) of the Hong Kong Government ITS/348/18FXSpecial Development Funding of Hong Kong Baptist University SDF18-0319-P0
6 · The paper itself

Abstract

Peptides are strings of approximately 2-50 amino acids, which have gained huge attention for theranostic applications in cancer research due to their various advantages including better biosafety, customizability, convenient process of synthesis, targeting ability via recognizing biological receptors on cancer cells, and better ability to penetrate cell membranes. The conjugation of peptides to the various nano delivery systems (NDS) has been found to provide an added benefit toward targeted delivery for cancer therapy. Moreover, the simultaneous delivery of peptide-conjugated NDS and nano probes has shown potential for the diagnosis of the malignant progression of cancer. In this review, various barriers hindering the targeting capacity of NDS are addressed, and various approaches for conjugating peptides and NDS have been discussed. Moreover, major peptide-based functionalized NDS targeting cancer-specific receptors have been considered, including the conjugation of peptides with extracellular vesicles, which are biological nanovesicles with promising ability for therapy and the diagnosis of cancer.

Indexed as

cancerextracellular vesiclespeptidetargeted nano deliverytheranostic

Identifiers

PMID34575511
PMCPMC8471603

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.