Evidence map›Paper›PMID 34575432›Full record

ArticlePharmaceutics2021

Anti-Cancer Nanopowders and MAPLE-Fabricated Thin Films Based on SPIONs Surface Modified with Paclitaxel Loaded β-Cyclodextrin.

Rebecca Alexandra Puiu, Paul Cătălin Balaure, Ema Constantinescu, Alexandru Mihai Grumezescu, Ecaterina Andronescu, Ovidiu-Cristian Oprea, Bogdan Stefan Vasile, Valentina Grumezescu, Irina Negut, Ionela Cristina Nica and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
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  10. New FeAntibiotics (Basel, Switzerland) · 2024
    Article
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  14. Novel Anticancer Strategies II.Pharmaceutics · 2023
    Article
  15. Article
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  18. Review
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  20. Antimicrobial Resistance and Inorganic Nanoparticles.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Rebecca Alexandra PuiuDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, Romania.ORCID 0000-0002-3280-4922
Paul Cătălin Balaure"Costin Nenitzescu" Department of Organic Chemistry, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, Romania.
Ema ConstantinescuDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, Romania.
Alexandru Mihai GrumezescuDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, Romania.ORCID 0000-0003-3036-094X
Ecaterina AndronescuDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, Romania.ORCID 0000-0002-2226-5849
Ovidiu-Cristian OpreaDepartment of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Politehnica University of Bucharest, 011061 Bucharest, Romania.ORCID 0000-0002-8145-1094
Bogdan Stefan VasileDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, Romania.ORCID 0000-0002-2267-6453
Valentina GrumezescuLasers Department, National Institute for Lasers, Plasma and Radiation Physics, 077125 Magurele, Romania.
Irina NegutLasers Department, National Institute for Lasers, Plasma and Radiation Physics, 077125 Magurele, Romania.ORCID 0000-0003-4038-7548
Ionela Cristina NicaResearch Institute of the University of Bucharest-ICUB, University of Bucharest, 050657 Bucharest, Romania.ORCID 0000-0003-4883-3346
Miruna Silvia StanResearch Institute of the University of Bucharest-ICUB, University of Bucharest, 050657 Bucharest, Romania.ORCID 0000-0002-6273-8540
Universitatea Națională de Știință și Tehnologie Politehnica București · ROUniversity of Bucharest · RONational Institute for Laser Plasma and Radiation Physics · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Globally, cancer is the second most common cause of death, and Europe accounts for almost 25% of the global cancer burden, although its people make up only 10% of the world's population. Conventional systemically administered anti-cancer drugs come with important drawbacks such as inefficiency due to poor bioavailability and improper biodistribution, severe side effects associated with low therapeutic indices, and the development of multidrug resistance. Therefore, smart nano-engineered targeted drug-delivery systems with tailored pharmacokinetics and biodistribution which can selectively deliver anti-cancer agents directly to the tumor site are the solution to most difficulties encountered with conventional therapeutic tools. Here, we report on the synthesis, physicochemical characterization, and in vitro evaluation of biocompatibility and anti-tumor activity of novel magnetically targetable SPIONs based on magnetite (Fe

Indexed as

paclitaxelSPIONsβ-Cyclodextrin

Identifiers

PMID34575432
PMCPMC8468465
OpenAlexW3197412208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.