Evidence map›Paper›PMID 34575398›Full record

ReviewJournal of clinical medicine2021

Less Known Gastrointestinal Manifestations of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome: A Systematic Review of the Literature.

Djordje Jevtic, Igor Dumic, Terri Nordin, Amteshwar Singh, Nadezda Sulovic, Milan Radovanovic, Mladen Jecmenica, Tamara Milovanovic

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Hypersensitivity Reactions to Anticonvulsants.Current allergy and asthma reports · 2025
    Review
  8. Article
  9. DRESS Syndrome Mimicking Postoperative Cholestasis: A Case Report.Clinical medicine insights. Case reports · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Djordje JevticSchool of Medicine, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0003-3790-3951
Igor DumicMayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
Terri NordinMayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
Amteshwar SinghDepartment of Hospital Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0001-7647-688X
Nadezda SulovicSchool of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Milan RadovanovicMayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
Mladen JecmenicaGastroenterology Fellowship Program, The Wright Center for Graduate Medical Education, Scranton, PA 18501, USA.
Tamara MilovanovicSchool of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Mayo Clinic · USUniversity of Belgrade · RSJohns Hopkins University · USThe Wright Center for Graduate Medical Education · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a potentially life threatening severe cutaneous drug reaction. Most patients develop eosinophilia, a rash, a fever, lymphadenopathy and variable visceral organ involvement 2-6 weeks following exposure to the inciting medication. Unlike other severe cutaneous drug reactions, internal organ involvement that leads to high mortality is a unique feature of DRESS syndrome. While the liver is the most common internal organ involved, literally every other visceral organ can be affected in this syndrome. The lesser-known gastrointestinal manifestations of this syndrome include esophagitis, gastritis, enteritis, colitis, pancreatitis and a late autoimmune sequela due to pancreatic injury such as fulminant type 1 diabetes mellitus, autoimmune type 1 diabetes mellitus and type 2 diabetes mellitus. While these entities are less common, they are associated with equally severe complications and adverse patient outcomes. In this review, we synthetize data on these rare manifestations using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The liver, the most common visceral organ involved, has been described as part of DRESS elsewhere and is not included in the scope of this article.

Indexed as

colitisdiabetes mellitusDRESS syndromedrug reactionenteritiseosinophiliaesophagitispancreatitis

Identifiers

PMID34575398
PMCPMC8467470
OpenAlexW3199203413

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.