Evidence map›Paper›PMID 34575363›Full record

ArticleJournal of clinical medicine2021

Sex Differences in Chronic Thromboembolic Pulmonary Hypertension. Treatment Options over Time in a National Referral Center.

Alejandro Cruz-Utrilla, María José Cristo-Ropero, Miguel Calderón-Flores, Maite Velázquez, María Jesús López-Gude, Yolanda Revilla Ostolaza, José Luis Pérez Vela, Javier de la Cruz-Bértolo, Héctor Bueno, Fernando Arribas Ynsaurriaga and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Alejandro Cruz-UtrillaPulmonary Hypertension Unit, Department of Cardiology, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.ORCID 0000-0002-3851-4037
María José Cristo-RoperoDepartment of Cardiology, Hospital Universitario de Torrejón, 28850 Torrejón de Ardoz, Spain.
Miguel Calderón-FloresDepartment of Cardiology, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.ORCID 0000-0002-4155-7505
Maite VelázquezCentro de Investigación Biomédica en Red en Enfermedades Cardiovasculares, Instituto de Salud Carlos III (CIBERCV), 28041 Madrid, Spain.ORCID 0000-0002-0303-0796
María Jesús López-GudeDepartment of Cardiac Surgery, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
Yolanda Revilla OstolazaDepartment of Radiology, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
José Luis Pérez VelaDepartment of Intensive Care Medicine, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
Javier de la Cruz-BértoloEpidemiology & Health Service/Technology Asessment, Instituto de Investigación Sanitaria del Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
Héctor BuenoCentro de Investigación Biomédica en Red en Enfermedades Cardiovasculares, Instituto de Salud Carlos III (CIBERCV), 28041 Madrid, Spain.
Fernando Arribas YnsaurriagaCentro de Investigación Biomédica en Red en Enfermedades Cardiovasculares, Instituto de Salud Carlos III (CIBERCV), 28041 Madrid, Spain.
José María CortinaDepartment of Cardiac Surgery, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
Pilar Escribano-SubiasPulmonary Hypertension Unit, Department of Cardiology, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.ORCID 0000-0002-6640-4839
Hospital Universitario 12 De Octubre · ESInstituto de Salud Carlos III · ESHospital Universitario de Torrejón · ES

Funding

Instituto de Salud Carlos III CM20/00164
6 · The paper itself

Abstract

(1) Background: Clinical presentation, disease distribution, or treatment received may provide insights into the reasons contributing to sex differences in chronic thromboembolic pulmonary hypertension (CTEPH). (2) Methods: We evaluated 453 patients (56% women) between 2007-2019. Data was collected from REHAP (Registro Español de Hipertensión Arterial Pulmonar) registry. Two time periods were selected to evaluate the influence of new treatments over time. (3) Results: Women were older. Baseline functional class was worse, and distance walked shorter in women compared with men. Women had higher pulmonary vascular resistances. Despite this, pulmonary endarterectomy (PEA) was carried out in more men, and women received more frequently pulmonary vasodilators exclusively. The 2014-2019 interval was associated with a better survival only among women. Interestingly, women had a more distal disease during this second period of time. (4) Conclusions: Even though women were older, and received invasive treatments less frequently, mortality was similar in both sexes. The introduction of balloon pulmonary angioplasty and the improvement of pulmonary endarterectomy, especially during the last years, could be associated with a survival benefit among women.

Indexed as

chronic thromboembolic pulmonary hypertensionpulmonary hypertensionwomen in cardiology

Identifiers

PMID34575363
PMCPMC8466098
OpenAlexW3200997958

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.