Evidence map›Paper›PMID 34575337›Full record

ArticleJournal of clinical medicine2021

High Oxygen Does Not Increase Reperfusion Injury Assessed with Lipid Peroxidation Biomarkers after Cardiac Arrest: A Post Hoc Analysis of the COMACARE Trial.

Jaana Humaloja, Maximo Vento, Julia Kuligowski, Sture Andersson, José David Piñeiro-Ramos, Ángel Sánchez-Illana, Erik Litonius, Pekka Jakkula, Johanna Hästbacka, Stepani Bendel and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Jaana HumalojaDepartment of Emergency Care and Services, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, Finland.ORCID 0000-0003-1092-6803
Maximo VentoNeonatal Research Group, Health Research Institute La Fe, 46026 Valencia, Spain.ORCID 0000-0003-0061-4742
Julia KuligowskiNeonatal Research Group, Health Research Institute La Fe, 46026 Valencia, Spain.ORCID 0000-0001-6979-2235
Sture AnderssonPediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, Finland.
José David Piñeiro-RamosNeonatal Research Group, Health Research Institute La Fe, 46026 Valencia, Spain.ORCID 0000-0003-1628-9075
Ángel Sánchez-IllanaNeonatal Research Group, Health Research Institute La Fe, 46026 Valencia, Spain.ORCID 0000-0001-7630-0614
Erik LitoniusDepartment of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, Finland.
Pekka JakkulaDepartment of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, Finland.
Johanna HästbackaDepartment of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, Finland.
Stepani BendelDepartment of Anesthesiology and Intensive Care, University of Eastern Finland and Kuopio University Hospital, 70029 Kuopio, Finland.
Marjaana TiainenDepartment of Neurology, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, Finland.
Matti ReinikainenDepartment of Anesthesiology and Intensive Care, University of Eastern Finland and Kuopio University Hospital, 70029 Kuopio, Finland.ORCID 0000-0001-6878-3740
Markus B SkrifvarsDepartment of Emergency Care and Services, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, Finland.
University of Helsinki · FILeitat Technological Center · ESUniversity of Eastern Finland · FI

Funding

Finska Läkaresällskapet N/AHelsingin Yliopiston Tiedesäätiö N/AInstituto de Investigación en Salud Carlos III CP16/00034; PI17/00127Medicinska Understödsföreningen Liv och Hälsa N/APerklen Stiftelse N/ASigrid Juséliuksen Säätiö N/ASvenska Kulturfonden N/A
6 · The paper itself

Abstract

The products of polyunsaturated fatty acid peroxidation are considered reliable biomarkers of oxidative injury in vivo. We investigated ischemia-reperfusion-related oxidative injury by determining the levels of lipid peroxidation biomarkers (isoprostane, isofuran, neuroprostane, and neurofuran) after cardiac arrest and tested the associations between the biomarkers and different arterial oxygen tensions (PaO

Indexed as

isoprostaneslipid peroxidesneuroprostanesout-of-hospital cardiac arrestreperfusion injury

Identifiers

PMID34575337
PMCPMC8471647
OpenAlexW3199292119

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.