ReviewJournal of clinical medicine2021
Age-Associated Increase in Thrombogenicity and Its Correlation with von Willebrand Factor.
Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Risk factors and surrogate indicators for cardiovascular disease are prevalent in Common Variable Immunodeficiency and associate with inflammatory phenotype.Frontiers in immunology · 2026Article
- Review
- Beyond the count: platelet dysfunction profile in pediatric trauma patients.Research and practice in thrombosis and haemostasis · 2025Article
- A Long-Term Follow-Up Study in Immune-Mediated Thrombotic Thrombocytopenic Purpura: What Are the Outcomes?Journal of clinical medicine · 2023Article
- Age-specific impact of type I interferons on cerebral thrombosis and inflammation.Blood advances · 2023Article
- Cadmium, von Willebrand factor and vascular aging.npj aging · 2023Review
- Lower levels of vWF are associated with lower risk of cardiovascular disease.Research and practice in thrombosis and haemostasis · 2022Article
- Transplantation of umbilical cord-derived mesenchymal stem cells promotes the recovery of thin endometrium in rats.Scientific reports · 2022Article
- Effective prediction model for preventing postoperative deep vein thrombosis during bladder cancer treatment.The Journal of international medical research · 2022Article
- Alteration of plasma von Willebrand factor in the treatment of retinal vein occlusion with cystoid macular edema.PloS one · 2022Article
- Ageing- and AAA-associated differentially expressed proteins identified by proteomic analysis in mice.PeerJ · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Endothelial cells that cover the lumen of all blood vessels have the inherent capacity to express both pro and anticoagulant molecules. However, under normal physiological condition, they generally function to maintain a non-thrombogenic surface for unobstructed blood flow. In response to injury, certain stimuli, or as a result of dysfunction, endothelial cells release a highly adhesive procoagulant protein, von Willebrand factor (VWF), which plays a central role in formation of platelet aggregates and thrombus generation. Since VWF expression is highly restricted to endothelial cells, regulation of its levels is among the most important functions of endothelial cells for maintaining hemostasis. However, with aging, there is a significant increase in VWF levels, which is concomitant with a significant rise in thrombotic events. It is not yet clear why and how aging results in increased VWF levels. In this review, we have aimed to discuss the age-related increase in VWF, its potential mechanisms, and associated coagulopathies as probable consequences.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.