Evidence map›Paper›PMID 34575265›Full record

ArticleJournal of clinical medicine2021

Feasibility and Outcomes of "No-Look No-Touch" Laparoscopic Radical Trachelectomy for Early-Stage Cervical Cancer.

Hiroyuki Kanao, Yoichi Aoki, Atsushi Fusegi, Makiko Omi, Hidetaka Nomura, Terumi Tanigawa, Sanshiro Okamoto, Tomoko Kurita, Sachiho Netsu, Kohei Omatsu and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06836869 (A Multicenter, Non-inferiority Trial to Compare the Effectiveness and Safety of Laparoscopic Radical Hysterectomy Incorporating Modified Tumor-free Techniques Versus Abdominal Radical Hysterectomy in Patients With Stage IB2 Cervical Cancer), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06836869 narecruitingnot on this mapstarted 2025, after this paper: background citation

A Multicenter, Non-inferiority Trial to Compare the Effectiveness and Safety of Laparoscopic Radical Hysterectomy Incorporating Modified Tumor-free Techniques Versus Abdominal Radical Hysterectomy in Patients With Stage IB2 Cervical Cancer

TypeinterventionalSponsorPeking Union Medical College HospitalRan2025 to 2032Enrolled524ConditionsCervical Cancer Stage IB2ArmsLaparoscopic radical hysterectomy incorporating modified tumor-free techniques, Abdominal radical hysterectomy
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Hiroyuki KanaoDepartment of Gynecologic Oncology, Cancer Institute Hospital, Tokyo 135-8550, Japan.
Yoichi AokiDepartment of Gynecologic Oncology, Cancer Institute Hospital, Tokyo 135-8550, Japan.
Atsushi FusegiDepartment of Gynecologic Oncology, Cancer Institute Hospital, Tokyo 135-8550, Japan.
Makiko OmiDepartment of Gynecologic Oncology, Cancer Institute Hospital, Tokyo 135-8550, Japan.
Hidetaka NomuraDepartment of Gynecologic Oncology, Cancer Institute Hospital, Tokyo 135-8550, Japan.
Terumi TanigawaDepartment of Gynecologic Oncology, Cancer Institute Hospital, Tokyo 135-8550, Japan.
Sanshiro OkamotoDepartment of Gynecologic Oncology, Cancer Institute Hospital, Tokyo 135-8550, Japan.
Tomoko KuritaDepartment of Gynecologic Oncology, Hospital of the University of Occupational and Environmental Health, Fukuoka 807-8556, Japan.
Sachiho NetsuDepartment of Gynecologic Oncology, Cancer Institute Hospital, Tokyo 135-8550, Japan.
Kohei OmatsuDepartment of Gynecologic Oncology, Cancer Institute Hospital, Tokyo 135-8550, Japan.
Mayu YunokawaDepartment of Gynecologic Oncology, Cancer Institute Hospital, Tokyo 135-8550, Japan.
The Cancer Institute Hospital · JPUniversity of Occupational and Environmental Health Japan · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intraoperative tumor manipulation and dissemination may compromise the survival of women with early-stage cervical cancer who undergo laparoscopic surgery. This study aimed to examine survival and obstetrical outcomes related to laparoscopic radical trachelectomy (LRT) with a "no-look no-touch" technique in 40 women. This technique incorporates five measures to prevent tumor spillage and damage to the uterine artery perfusion. Five LRTs were aborted because of positive nodes or positive surgical margins. Compared with those of type III laparoscopic radical hysterectomy, the surgical outcomes of LRT in 35 patients were acceptable: operative time (380 min), estimated blood loss (140 mL), length of hospital stay (15 days), and lengths of excised parametrium and vagina. During follow-up (median, 41.3 months), the 5-year disease-free survival and overall survival were 95.0% (95% CI: 69.5-99.3%) and 100%, respectively. Of the nine patients (26%) who attempted pregnancy, seven conceived (nine pregnancies, 76%). Eight were delivered by term cesarean section, while one was miscarried in the first trimester. Our study suggests that the no-look no-touch technique may be effective in reducing the risk of recurrence and improving obstetrical outcomes during LRT for early-stage cervical cancer.

Indexed as

cervical cancerdeliverylaparoscopypregnancyradical trachelectomysurvivaluterine artery

Identifiers

PMID34575265
PMCPMC8467639
OpenAlexW3199993264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.