Evidence map›Paper›PMID 34575259›Full record

ArticleJournal of clinical medicine2021

Comparative Analysis of the Kinetic Behavior of Systemic Inflammatory Markers in Patients with Depressed versus Preserved Left Ventricular Function Undergoing Transcatheter Aortic Valve Implantation.

Haitham Abu Khadija, Gera Gandelman, Omar Ayyad, Lion Poles, Michael Jonas, Offir Paz, Sorel Goland, Sara Shimoni, Valery Meledin, Jacob George and 1 more

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Association of the CALLY Index With 30-Day Outcomes After Transcatheter Aortic Valve Replacement.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haitham Abu KhadijaKaplan Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University, Jerusalem 76610, Israel.ORCID 0000-0002-2336-3125
Gera GandelmanKaplan Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University, Jerusalem 76610, Israel.
Omar AyyadKaplan Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University, Jerusalem 76610, Israel.
Lion PolesKaplan Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University, Jerusalem 76610, Israel.
Michael JonasKaplan Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University, Jerusalem 76610, Israel.
Offir PazKaplan Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University, Jerusalem 76610, Israel.
Sorel GolandKaplan Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University, Jerusalem 76610, Israel.
Sara ShimoniKaplan Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University, Jerusalem 76610, Israel.
Valery MeledinKaplan Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University, Jerusalem 76610, Israel.
Jacob GeorgeKaplan Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University, Jerusalem 76610, Israel.
Alex BlattKaplan Heart Center, Kaplan Medical Center, Rehovot, Affiliated with the Hebrew University, Jerusalem 76610, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrior studies have proven the safety and efficacy of transcatheter aortic valve implantation (TAVI) in patients with reduced left ventricular (LV) function. This study's aim was to investigate periprocedural inflammatory responses after TAVI.

methodsPatients with severe symptomatic aortic stenosis and reduced LV function who underwent transfemoral TAVI were enrolled. A paired-matched analysis (1:2 ratio) was performed using patients with preserved LV function. Whole white blood cells (WBC) and subpopulation dynamics as well as the neutrophil to lymphocyte ratio (NLR) were evaluated at different times.

resultsA total of 156 patients were enrolled, including 52 patients with LVEF < 40% 35.00 [30.00, 39.25] and 104 with LVEF > 50% 55.00 [53.75, 60.0],

conclusionsTAVI for severe symptomatic aortic stenosis, with reduced LV function, was associated with an improvement in the inflammatory profile that may account for some of the observable benefits of the procedure in this subset of patients.

Indexed as

inflammationLVEFneutrophil–lymphocyte ratioNLRreduced LVEFTAVITAVR

Identifiers

PMID34575259
PMCPMC8467631

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.