Evidence map›Paper›PMID 34575250›Full record

ArticleJournal of clinical medicine2021

Associations between Clinical Findings and Severity of Diffuse Idiopathic Skeletal Hyperostosis in Patients with Ossification of the Posterior Longitudinal Ligament.

Takashi Hirai, Soraya Nishimura, Toshitaka Yoshii, Narihito Nagoshi, Jun Hashimoto, Kanji Mori, Satoshi Maki, Keiichi Katsumi, Kazuhiro Takeuchi, Shuta Ushio and 28 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors at 19 institutions in 1 country.

Takashi HiraiDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan.
Soraya NishimuraDepartment of Orthopedic Surgery, School of Medicine, Keio University, Shinjuku, Tokyo 160-8582, Japan.
Toshitaka YoshiiDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan.
Narihito NagoshiDepartment of Orthopedic Surgery, School of Medicine, Keio University, Shinjuku, Tokyo 160-8582, Japan.
Jun HashimotoDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan.
Kanji MoriDepartment of Orthopaedic Surgery, Shiga University of Medical Science, Ōtsu 520-2192, Japan.
Satoshi MakiDepartment of Orthopedic Surgery, School of Medicine, Chiba University Graduate, Chiba 260-0856, Japan.
Keiichi KatsumiDepartment of Orthopedic Surgery, Niigata University Medical and Dental General Hospital, Niigata 951-8520, Japan.
Kazuhiro TakeuchiNational Hospital Organization Okayama Medical Center, Department of Orthopedic Surgery, Okayama 701-1192, Japan.
Shuta UshioDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan.ORCID 0000-0001-5422-7655
Takeo FuruyaDepartment of Orthopedic Surgery, School of Medicine, Chiba University Graduate, Chiba 260-0856, Japan.
Kei WatanabeDepartment of Orthopedic Surgery, Niigata University Medical and Dental General Hospital, Niigata 951-8520, Japan.
Norihiro NishidaDepartment of Orthopedic Surgery, Graduate School of Medicine, Yamaguchi University, Yamaguchi 755-8505, Japan.ORCID 0000-0001-7754-6579
Kota WatanabeDepartment of Orthopedic Surgery, School of Medicine, Keio University, Shinjuku, Tokyo 160-8582, Japan.
Takashi KaitoDepartment of Orthopaedic Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Osaka, Japan.ORCID 0000-0003-4882-2997
Satoshi KatoDepartment of Orthopedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa 920-1192, Japan.ORCID 0000-0003-4762-5932
Katsuya NagashimaDepartment of Orthopedic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8577, Japan.
Masao KodaDepartment of Orthopedic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8577, Japan.
Hiroaki NakashimaDepartment of Orthopedics, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Shouwa-ku, Nagoya 466-8560, Japan.ORCID 0000-0002-0039-9678
Shiro ImagamaDepartment of Orthopedics, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Shouwa-ku, Nagoya 466-8560, Japan.
Kazuma MurataDepartment of Orthopedic Surgery, Tokyo Medical University, Shinjuku, Tokyo 160-8402, Japan.
Yuji MatsuokaDepartment of Orthopedic Surgery, Tokyo Medical University, Shinjuku, Tokyo 160-8402, Japan.
Kanichiro WadaDepartment of Orthopaedic Surgery, Graduate School of Medicine, Hirosaki University, Hirosaki 036-8562, Japan.
Atsushi KimuraDepartment of Orthopedics, Jichi Medical University, Shimotsuke 329-0498, Japan.ORCID 0000-0003-4948-1792
Tetsuro OhbaDepartment of Orthopedic Surgery, University of Yamanashi, Chuo 409-3898, Japan.
Hiroyuki KatohDepartment of Orthopedic Surgery, Surgical Science, School of Medicine, Tokai University, Isehara 259-1193, Japan.ORCID 0000-0003-0046-3008
Masahiko WatanabeDepartment of Orthopedic Surgery, Surgical Science, School of Medicine, Tokai University, Isehara 259-1193, Japan.ORCID 0000-0001-9038-0446
Yukihiro MatsuyamaDepartment of Orthopedic Surgery, School of Medicine, Hamamatsu University, Hamamatsu 431-3125, Japan.
Hiroshi OzawaDepartment of Orthopaedic Surgery, Tohoku Medical and Pharmaceutical University, Sendai 983-8536, Japan.
Hirotaka HaroDepartment of Orthopedic Surgery, University of Yamanashi, Chuo 409-3898, Japan.
Katsushi TakeshitaDepartment of Orthopedics, Jichi Medical University, Shimotsuke 329-0498, Japan.
Morio MatsumotoDepartment of Orthopedic Surgery, School of Medicine, Keio University, Shinjuku, Tokyo 160-8582, Japan.
Masaya NakamuraDepartment of Orthopedic Surgery, School of Medicine, Keio University, Shinjuku, Tokyo 160-8582, Japan.
Masashi YamazakiDepartment of Orthopedic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8577, Japan.ORCID 0000-0002-9293-3531
Yu MatsukuraDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan.
Hiroyuki InoseDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan.ORCID 0000-0003-4195-2545
Atsushi OkawaDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan.
Yoshiharu KawaguchiDepartment of Orthopedic Surgery, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.
Tokyo Medical and Dental University · JPKeio University · JPUniversity of Tsukuba · JPChiba University · JPJichi Medical University · JPNagoya University · JPTokai University · JPTokyo Medical University · JPUniversity of Yamanashi · JPHamamatsu University · JPHirosaki University · JPKanazawa University · JPNational Hospital Organization · JPNiigata University Medical and Dental Hospital · JPShiga University of Medical Science · JPThe University of Osaka · JPTohoku Medical and Pharmaceutical University · JPUniversity of Toyama · JPYamaguchi University · JP

Funding

Japan Agency for Medical Research and Development 16ek0109136h0002Ministry of Health, Labour and Welfare 201610008B
6 · The paper itself

Abstract

backgroundThis study investigated how diffuse idiopathic skeletal hyperostosis (DISH) influences clinical characteristics in patients with cervical ossification of the posterior longitudinal ligament (OPLL). Although DISH is considered unlikely to promote neurologic dysfunction, this relationship remains unclear.

methodsPatient data were prospectively collected from 16 Japanese institutions. In total, 239 patients with cervical OPLL were enrolled who had whole-spine computed tomography images available. The primary outcomes were visual analog scale pain scores and the results of other self-reported clinical questionnaires. Correlations were sought between clinical symptoms and DISH using the following grading system: 1, DISH at T3-T10; 2, DISH at both T3-10 and C6-T2 and/or T11-L2; and 3, DISH beyond the C5 and/or L3 levels.

resultsDISH was absent in 132 cases, grade 1 in 23, grade 2 in 65, and grade 3 in 19. There were no significant correlations between DISH grade and clinical scores. However, there was a significant difference in the prevalence of neck pain (but not in back pain or low back pain) among the three grades. Interestingly, DISH localized in the thoracic spine (grade 1) may create overload at the cervical spine and lead to neck pain in patients with cervical OPLL.

conclusionThis study is the first prospective multicenter cross-sectional comparison of subjective outcomes in patients with cervical OPLL according to the presence or absence of DISH. The severity of DISH was partially associated with the prevalence of neck pain.

Indexed as

cervical spineclinical findingscomputed tomographydiffuse idiopathic skeletal hyperostosisossification of the posterior longitudinal ligamentpainpatient-reported outcomeswhole spine

Identifiers

PMID34575250
PMCPMC8468753
OpenAlexW3201501676

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.