ArticleJournal of clinical medicine2021
Severe Traumatic Injury Induces Phenotypic and Functional Changes of Neutrophils and Monocytes.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Beyond injury severity: monocyte-associated small extracellular vesicles distinguish respiratory-support trajectories following thoracic trauma.BMC pulmonary medicine · 2026Article
- Functional immune changes are conserved in COVID-19 and trauma patients receiving intensive care.Nature communications · 2026Article
- Editorial: Unveiling immune biomarkers: advancing trauma care through cellular and vesicular insights.Frontiers in immunology · 2025Article
- Long-lasting changes in circulating dendritic cell and monocyte subsets, and altered expression of EMR2, CD97 and EMR3 on these cells in the posttraumatic course.Clinical & translational immunology · 2025Article
- An Albumin, Neutrophil, and Lymphocyte-Related Risk Estimation Tool in Hospitalised Patients.Cureus · 2024Article
- Article
- Elevation of White Blood Cell Subtypes in Adult Trauma Patients with Stress-Induced Hyperglycemia.Diagnostics (Basel, Switzerland) · 2023Article
- Systemic immune response in young and elderly patients after traumatic brain injury.Immunity & ageing : I & A · 2023Article
- Liquid Biopsy in Organ Damage: small extracellular vesicle chip-based assessment of polytrauma.Frontiers in immunology · 2023Article
- The role of neutrophil extracellular traps in acute lung injury.Frontiers in immunology · 2022Review
- Circulating monocytes in acute pancreatitis.Frontiers in immunology · 2022Review
- The peripheral and decidual immune cell profiles in women with recurrent pregnancy loss.Frontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundSevere traumatic injury has been associated with high susceptibility for the development of secondary complications caused by dysbalanced immune response. As the first line of the cellular immune response, neutrophils and monocytes recruited to the site of tissue damage and/or infection, are divided into three different subsets according to their CD16/CD62L and CD16/CD14 expression, respectively. Their differential functions have not yet been clearly understood. Thus, we evaluated the phenotypic changes of neutrophil and monocyte subsets among their functionality regarding oxidative burst and the phagocytic capacity in severely traumatized patients.
methodsPeripheral blood was withdrawn from severely injured trauma patients (TP;
resultsIn TP, the counts of immature neutrophils were significantly increased vs. HV. The numbers of mature and CD62L
conclusionsNeutrophils and monocytes display a phenotypic shift following severe injury. The increased functional abnormalities of certain subsets may contribute to the dysbalanced immune response and attenuate the antimicrobial function and thus, may represent a potential therapeutic target. Further studies on isolated subsets are necessary for evaluation of their physiological role after severe traumatic injury.
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