Evidence map›Paper›PMID 34575230›Full record

ArticleJournal of clinical medicine2021

Management of Spontaneous Bleeding in COVID-19 Inpatients: Is Embolization Always Needed?

Pascale Riu, Fabrizio Albarello, Federica Di Stefano, Alessandra Vergori, Alessandra D'Abramo, Carlo Cerini, Martina Nocioni, Maurizio Morucci, Nardi Tetaj, Massimo Cristofaro and 9 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

Pascale RiuInterventional Radiologist Unit, Azienda Ospedaliera San Camillo Forlanini, 00149 Rome, Italy.
Fabrizio AlbarelloRadiology Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.ORCID 0000-0001-5115-709X
Federica Di StefanoRadiology Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.ORCID 0000-0001-7449-2392
Alessandra VergoriHIV/AIDS Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.ORCID 0000-0001-6944-0686
Alessandra D'AbramoEmerging Infectious Diseases Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.
Carlo CeriniHIV/AIDS Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.
Martina NocioniIntensive Care Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.
Maurizio MorucciInterventional Radiologist Unit, Azienda Ospedaliera San Camillo Forlanini, 00149 Rome, Italy.
Nardi TetajIntensive Care Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.ORCID 0000-0002-2906-4855
Massimo CristofaroRadiology Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.ORCID 0000-0002-0224-5760
Vincenzo SchininàRadiology Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.
Paolo CampioniRadiology Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.ORCID 0000-0002-7275-7358
Ada PetroneRadiology Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.ORCID 0000-0002-3413-4475
Nicoletta FuscoRadiology Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.
Luisa MarchioniIntensive Care Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.
Andrea AntinoriHIV/AIDS Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.
Emanuele NicastriEmerging Infectious Diseases Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.ORCID 0000-0002-5606-8712
Roberto CianniInterventional Radiologist Unit, Azienda Ospedaliera San Camillo Forlanini, 00149 Rome, Italy.
Stefania IannielloRadiology Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITAzienda Ospedaliera San Camillo-Forlanini · IT

Funding

Ministero della Salute COVID-2020-12371675
6 · The paper itself

Abstract

backgroundcritically ill patients with SARS-CoV-2 infection present a hypercoagulable condition. Anticoagulant therapy is currently recommended to reduce thrombotic risk, leading to potentially severe complications like spontaneous bleeding (SB). Percutaneous transcatheter arterial embolization (PTAE) can be life-saving in critical patients, in addition to medical therapy. We report a major COVID-19 Italian Research Hospital experience during the pandemic, with particular focus on indications and technique of embolization.

methodsWe retrospectively included all subjects with SB and with a microbiologically confirmed SARS-CoV-2 infection, over one year of pandemic, selecting two different groups: (a) patients treated with PTAE and medical therapy; (b) patients treated only with medical therapy. Computed tomography (CT) scan findings, clinical conditions, and biological findings were collected.

results21/1075 patients presented soft tissue SB with an incidence of 1.95%. 10/21 patients were treated with PTAE and medical therapy with a 30-days survival of 70%. Arterial blush, contrast late enhancement, and dimensions at CT scan were found discriminating for the embolization (

conclusionsPTAE is an important tool in severely ill, bleeding COVID-19 patients. The decision for PTAE of COVID-19 patients must be carefully weighted with particular attention paid to the clinical and biological condition, hematoma location and volume.

Indexed as

COVID-19low-molecular-weight heparinpercutaneous trans arterial embolizationspontaneous bleeding

Identifiers

PMID34575230
PMCPMC8469448
OpenAlexW3199015757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.