Evidence map›Paper›PMID 34575170›Full record

ArticleJournal of clinical medicine2021

The Prognostic Role of Neutrophil-to-Lymphocyte Ratio in Patients Hospitalized with Acute Pulmonary Embolism.

Orly Efros, Tal Beit Halevi, Eshcar Meisel, Shelly Soffer, Noam Barda, Omri Cohen, Gili Kenet, Aharon Lubetsky

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The Diagnostic Value of the Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio for Deep Venous Thrombosis: A Systematic Review and Meta-Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Orly EfrosNational Hemophilia Center and Thrombosis & Hemostasis Institute, Sheba Medical Center, Ramat-Gan 5262000, Israel.ORCID 0000-0002-6024-9110
Tal Beit HaleviSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6927846, Israel.ORCID 0000-0003-3798-8684
Eshcar MeiselSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6927846, Israel.
Shelly SofferAssuta Medical Center, Ashdod 7747629, Israel.ORCID 0000-0002-7853-2029
Noam BardaClalit Research Institute, Clalit Health Services, Ramat-Gan 6578898, Israel.ORCID 0000-0002-3400-235X
Omri CohenNational Hemophilia Center and Thrombosis & Hemostasis Institute, Sheba Medical Center, Ramat-Gan 5262000, Israel.ORCID 0000-0002-8328-9748
Gili KenetNational Hemophilia Center and Thrombosis & Hemostasis Institute, Sheba Medical Center, Ramat-Gan 5262000, Israel.
Aharon LubetskyNational Hemophilia Center and Thrombosis & Hemostasis Institute, Sheba Medical Center, Ramat-Gan 5262000, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early risk stratification is essential for determining the appropriate therapeutic management approach of pulmonary embolism (PE). This study aimed to evaluate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in patients hospitalized with acute pulmonary embolism by investigating its association with mortality in a large-scale population diagnosed and hospitalized with acute PE. We retrieved all consecutive patients hospitalized in an internal medicine department or an intensive care unit in a tertiary medical center from December 2007 to April 2021 with a discharge diagnosis of pulmonary embolism. A total of 2072 patients were included. Patients with above-median NLR (i.e., 5.12) had a higher 30-day mortality risk (adjusted odds ratio (aOR), 2.82; 95% confidence interval (CI) 2.14-3.70) and higher one-year mortality risk (aOR, 2.51; 95% CI 2.04-3.08). Similar trends were demonstrated in a sub-analysis of patients without cancer and hemodynamically stable (i.e., systolic blood pressure over 90 mmHg). Furthermore, the median hospital length of stay in patients with an elevated NLR was higher, and so was the in-hospital mortality rate. Elevated NLR in acute PE is associated with a worse short-term and long-term prognosis and with a longer duration of hospitalization.

Indexed as

neutrophil-to-lymphocyte ratio (NLR)pulmonary embolism (PE)venous thromboembolism (VTE)

Identifiers

PMID34575170
PMCPMC8469500

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.