ReviewLife (Basel, Switzerland)2021
Elevation Mechanisms and Diagnostic Consideration of Cardiac Troponins under Conditions Not Associated with Myocardial Infarction. Part 1.
Review in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Review
- Recent developments in surface-enhanced Raman spectroscopy-based immuno (apta) assays for cardiac troponin detection: prospects for point-of-care applications.Biophysical reviews · 2026Review
- Development and validation of identification models for aortic dissection and non-ST-segment elevation acute coronary syndrome in the emergency department.Scientific reports · 2025Article
- Article
- The diagnostic and prognostic value of serum miR-199a-5p combined with echocardiography in acute myocardial infarction.Journal of cardiothoracic surgery · 2025Article
- Assay precision, 99th percentile reference value and proportion of detected healthy european adults for VIDAS® high-sensitive troponin I.Practical laboratory medicine · 2024Article
- [Acute ischemic stroke and troponin elevation: update of the Mannheim clinical algorithm].Innere Medizin (Heidelberg, Germany) · 2024Review
- The Metabolic Pathway of Cardiac Troponins Release: Mechanisms and Diagnostic Role.Cardiology research · 2022Review
- The Importance of Cardiac Troponin Metabolism in the Laboratory Diagnosis of Myocardial Infarction (Comprehensive Review).BioMed research international · 2022Review
- Metabolic Pathway of Cardiospecific Troponins: From Fundamental Aspects to Diagnostic Role (Comprehensive Review).Frontiers in molecular biosciences · 2022Review
- A review of cardiac troponin I detection by surface enhanced Raman spectroscopy: Under the spotlight of point-of-care testing.Frontiers in chemistry · 2022Review
- Troponin I is an independent marker of cardiovascular mortality risk in chronic kidney disease patients.Jornal brasileiro de nefrologiaArticle
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Authors and funding
1 author.
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No grant is acknowledged in the PubMed record.
Abstract
Although cardiac troponins are considered the most specific biomarkers for the diagnosis of acute myocardial infarction (AMI), their diagnostic consideration goes far beyond the detection of this dangerous disease. The mechanisms of cardiac troponin elevation are extremely numerous and not limited to ischemic necrosis of cardiac myocytes. Practitioners should be well aware of the underlying pathological and physiological conditions that can lead to elevated serum levels of cardiac troponins to avoid differential diagnostic errors, which will be greatly increased if clinicians rely on laboratory data alone. This article presents a classification of the main causes of an elevation in cardiac troponins and discusses in detail the mechanisms of such elevation and the diagnostic consideration of cardiac troponins in some conditions not associated with AMI, such as physical exertion, inflammatory heart diseases (myocarditis and endocarditis), pulmonary embolism (PE), renal failure, and systemic inflammation (sepsis).
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