Evidence map›Paper›PMID 34575061›Full record

ArticleLife (Basel, Switzerland)2021

High SPIN4 Expression Is Linked to Advanced Nodal Status and Inferior Prognosis in Nasopharyngeal Carcinoma Patients.

Shih-Lun Chang, Ti-Chun Chan, Tzu-Ju Chen, Ching-Chieh Yang, Hsin-Hwa Tsai, Cheng-Fa Yeh, Sung-Wei Lee, Hong-Yue Lai

Open access · goldAbstract read
In one paragraph

Article in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Clinical Observation of a Rare Binder Phenotype With Fetal Overgrowth Due to aMaternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Shih-Lun ChangDepartment of Otolaryngology, Chi Mei Medical Center, Tainan 710, Taiwan.
Ti-Chun ChanDepartment of Medical Research, Chi Mei Medical Center, Tainan 710, Taiwan.
Tzu-Ju ChenDepartment of Clinical Pathology, Chi Mei Medical Center, Tainan 710, Taiwan.
Ching-Chieh YangDepartment of Radiation Oncology, Chi Mei Medical Center, Tainan 710, Taiwan.ORCID 0000-0003-3823-4673
Hsin-Hwa TsaiDepartment of Medical Research, Chi Mei Medical Center, Tainan 710, Taiwan.
Cheng-Fa YehDepartment of Internal Medicine, Chi Mei Medical Center, Tainan 710, Taiwan.
Sung-Wei LeeDepartment of Radiation Oncology, Chi Mei Medical Center, Liouying 736, Taiwan.
Hong-Yue LaiDepartment of Medical Research, Chi Mei Medical Center, Tainan 710, Taiwan.ORCID 0000-0002-6197-9828
Chi Mei Medical Center · TWChung Hwa University of Medical Technology · TWNational Health Research Institutes · TWNational Sun Yat-sen University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nasopharyngeal carcinoma (NPC), characterized by the infiltration of lymphocytes, is a malignancy derived from the epithelium of the nasopharynx. Despite its sensitivity to radiation and chemotherapy, NPC has a high propensity for recurrence and metastasis. Although lymph node levels have been indicated as an independent prognostic factor for NPC, there has been no precise prognostic biomarker to predict clinical outcomes for NPC before advanced disease. In the present study, we surveyed differentially expressed genes in NPC via the next-generation sequencing (NGS)-based Oncomine database and identified the spindlin family member 4 (

Indexed as

advanced nodal statusnasopharyngeal carcinomaprognostic biomarkerSPIN4tight junction

Identifiers

PMID34575061
PMCPMC8470428
OpenAlexW3197784790

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.