ArticleLife (Basel, Switzerland)2021
Frailty in Stroke-A Narrated Review.
Article in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Frailty prediction models in older adults with stroke in China: A systematic review and meta-analysis.International journal of nursing studies advances · 2026Review
- Prevalence of frailty among older patients with acute ischemic stroke and its association with short-term functional outcome: a cohort study in Vietnam.BMC geriatrics · 2025Article
- Multidimensional Analysis of Frailty and Its Influencing Factors in Hospitalized Elderly Stroke Patients.Clinical interventions in aging · 2025Article
- Frailty after COVID-19: The wave after?Aging medicine (Milton (N.S.W)) · 2023Review
- Disease-Specific Quality of Life among Patients with Peripheral Artery Disease in Hungary.International journal of environmental research and public health · 2023Article
- Global Trends and Research Hotspots in Long COVID: A Bibliometric Analysis.International journal of environmental research and public health · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This narrative review provides a summary introduction to the relationship between stroke and physical and cognitive frailty syndromes and the neuro-inflammatory similarities (including inflammaging) between the two. The review argues the potential effects of Post COVID-19 Neurological Syndrome (PCNS, also known as Long COVID) with similar pathophysiology. Many patients who have suffered from acute stroke experience long-lasting symptoms affecting several organs including fatigue, brain fog, reduced physical activity, loss of energy, and loss of cognitive reserve, culminating in the loss of independence and poor quality of life. This is very similar to the emerging reports of PCNS from different parts of the world. Stroke, particularly in older adults with comorbidities appears to impact the health and welfare of patients by reducing central neuronal input and neuromuscular function, with muscular atrophy and neuropsychiatric complications. The cumulative effects can potentially lead to a range of physical and cognitive frailty syndromes, which, in many cases may be attributed to persistent, maladapted, low grade, chronic inflammation. Meanwhile, post-COVID-19 Neurological Syndrome (also known as Long COVID Syndrome) appears to share a similar trajectory, adding further urgency for investigations into the mechanisms underlying this constellation of symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.