ArticleInternational journal of environmental research and public health2021
Polystyrene Microplastics Exposure: An Insight into Multiple Organ Histological Alterations, Oxidative Stress and Neurotoxicity in Javanese Medaka Fish (
Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- A systematic review of the potential neurotoxicity of micro-and nanoplastics: the known and unknown.Particle and fibre toxicology · 2025Pooled it
- Neurophysiological and Behavioral Effects of Micro- and Nanoplastics in Aquatic Organisms.Animals : an open access journal from MDPI · 2026Review
- Polystyrene microplastics (PS-MPs) disturb skeleto-muscular energy metabolism and tissue architecture following sub-acute exposure: A dose-responsive study.Journal of muscle research and cell motility · 2025Article
- Effects of Microplastics and Nanoplastics Exposure on Neurogenesis: Are Thymidine Analogs a Good Option to Study Such Effects?International journal of molecular sciences · 2025Review
- Oxidative Stress and Neurotoxicity Biomarkers in Fish Toxicology.Antioxidants (Basel, Switzerland) · 2025Review
- Article
- Effects of Exposure to Different Types of Microplastics on the Growth and Development ofToxics · 2025Article
- Identification Tools of Microplastics from Surface Water Integrating Digital Image Processing and Statistical Techniques.Materials (Basel, Switzerland) · 2024Article
- Health effects of microplastics and nanoplastics: review of published case reports.Environmental analysis, health and toxicology · 2024Article
- Polystyrene nanoplastic and engine oil synergistically intensify toxicity in Nile tilapia, Oreochromis niloticus : Polystyrene nanoplastic and engine oil toxicity in Nile tilapia.BMC veterinary research · 2024Article
- Subchronic Exposure to Polystyrene Microplastic Differently Affects Redox Balance in the Anterior and Posterior Intestine ofAnimals : an open access journal from MDPI · 2023Article
- Are microplastics contributing to pollution-induced neurotoxicity? A pilot study with wild fish in a real scenario.Heliyon · 2023Article
- Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism.Frontiers in physiology · 2023Review
- Review
- The Burden of Microplastics Pollution and Contending Policies and Regulations.International journal of environmental research and public health · 2022Review
- Polystyrene microplastics induce gut microbiome and metabolome changes in Javanese medaka fish (Toxicology reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microplastics (MPs) have become pollutants of concern due to their unknown human health effect and negative impact on terrestrial and aquatic ecosystems. There is increasing number of experimental research on MPs globally with its effects not fully understood; recent animal studies explore its effects on the intestines, yet on other vital organs. Javanese medaka fish was exposed to polystyrene microplastics (PS-MPs) beads for a period of 21 days. Histological alterations, intestinal oxidative stress, permeability and neurotoxicity were evaluated. Significant inflammatory changes and tissue damage were observed in the intestine, liver and kidney. Intestinal oxidative stress and permeability were found to be significantly increased. In the brain, neurotoxicity characterised by a significant induction of oxidative stress, lipid peroxidation and the inhibition of acetylcholinesterase enzyme were elucidated. This study provided an insight into the multiple organ effect of microplastics exposure, necessitating further exploration and identification of biomarkers to be utilised for biomonitoring population at risk in the future.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.