ArticleFoods (Basel, Switzerland)2021
Combined Profiling of Transcriptome and DNA Methylome Reveal Genes Involved in Accumulation of Soluble Sugars and Organic Acid in Apple Fruits.
Article in Foods (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Epigenetic orchestration of sugar signaling in plant development and stress adaptation.Horticulture research · 2026Article
- The genomic design of fruit metabolomes.Plant communications · 2025Review
- Elucidating Sugar-Acid Metabolic Diversity and Screening Breeding Materials in Xinjiang Pear (Foods (Basel, Switzerland) · 2025Article
- Multidimensional Transcriptomics Reveals the Key Genes and Pathways Regulating the Acidity of Apples.Current issues in molecular biology · 2025Article
- Different starch sources and amino acid levels on growth performance, starch and amino acids digestion, absorption and metabolism of 0- to 3-week-old broilers fed low protein diet.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Allelic variation of MdMYB123 controls malic acid content by regulating MdMa1 and MdMa11 expression in apple.Plant physiology · 2023Article
- Transcriptome Analysis Reveals Potential Mechanisms of L-Serine Production byFoods (Basel, Switzerland) · 2022Article
- Characterization of the genetic and regulatory networks associated with sugar and acid metabolism in applesFrontiers in plant science · 2022Article
- Multi-Omics Landscape of DNA Methylation Regulates Browning in "Fuji" Apple.Frontiers in nutrition · 2021Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Organic acids and soluble sugars are the major determinants of fruit organoleptic quality. Additionally, DNA methylation has crucial regulatory effects on various processes. However, the epigenetic modifications in the regulation of organic acid and soluble sugar accumulation in apple fruits remain uncharacterized. In this study, DNA methylation and the transcriptome were compared between 'Honeycrisp' and 'Qinguan' mature fruits, which differ significantly regarding soluble sugar and organic acid contents. In both 'Honeycrisp' and 'Qinguan' mature fruits, the CG context had the highest level of DNA methylation, and then CHG and CHH contexts. The number and distribution of differentially methylated regions (DMRs) varied among genic regions and transposable elements. The DNA methylation levels in all three contexts in the DMRs were significantly higher in 'Honeycrisp' mature fruits than in 'Qinguan' mature fruits. A combined methylation and transcriptome analysis revealed a negative correlation between methylation levels and gene expression in DMRs in promoters and gene bodies in the CG and CHG contexts and in gene bodies in the CHH context. Two candidate genes (
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