ReviewFoods (Basel, Switzerland)2021
Alkenylbenzenes in Foods: Aspects Impeding the Evaluation of Adverse Health Effects.
Review in Foods (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Formation and persistence of estragole-derived DNA adducts in human liver cells and tissue.Archives of toxicology · 2026Article
- Transcription-coupled nucleotide excision repair protects against genomic instability and cell death induced by the liver toxin methyleugenol.Cell death & disease · 2026Article
- Environmental and internal drivers of genotoxic carcinogens accumulation in botanicals and their preparations.Archives of toxicology · 2025Review
- In Silico Network Toxicology, Molecular Docking, and Multi-Level Bioinformatics Reveal Methyl Eugenol-Induced Hepatocellular Carcinoma Mechanisms in Humans.Cancer medicine · 2025Article
- Comparative Analysis of Estragole, Methyleugenol, Myristicin, and Elemicin Regarding Micronucleus Formation in V79 Cells.Molecules (Basel, Switzerland) · 2025Article
- Bio-organic fertilizers promote yield, chemical composition, and antioxidant and antimicrobial activities of essential oil in fennel (Foeniculum vulgare) seeds.Scientific reports · 2023Article
- Occurrence of Alkenylbenzenes in Plants: Flavours and Possibly Toxic Plant Metabolites.Plants (Basel, Switzerland) · 2023Review
- Article
- Natural Compounds in Plant-Based Food.Foods (Basel, Switzerland) · 2023Article
- Article
- Natural toxins and One Health: a review.Science in One Health · 2022Review
- Food-Borne Chemical Carcinogens and the Evidence for Human Cancer Risk.Foods (Basel, Switzerland) · 2022Review
- Myristicin and Elemicin: Potentially Toxic Alkenylbenzenes in Food.Foods (Basel, Switzerland) · 2022Review
- A Comprehensive Database for DNA Adductomics.Frontiers in chemistry · 2022Article
- High Performance Liquid Chromatography versus Stacking-Micellar Electrokinetic Chromatography for the Determination of Potentially Toxic Alkenylbenzenes in Food Flavouring Ingredients.Molecules (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alkenylbenzenes are naturally occurring secondary plant metabolites, primarily present in different herbs and spices, such as basil or fennel seeds. Thus, alkenylbenzenes, such as safrole, methyleugenol, and estragole, can be found in different foods, whenever these herbs and spices (or extracts thereof) are used for food production. In particular, essential oils or other food products derived from the aforementioned herbs and spices, such as basil-containing pesto or plant food supplements, are often characterized by a high content of alkenylbenzenes. While safrole or methyleugenol are known to be genotoxic and carcinogenic, the toxicological relevance of other alkenylbenzenes (e.g., apiol) regarding human health remains widely unclear. In this review, we will briefly summarize and discuss the current knowledge and the uncertainties impeding a conclusive evaluation of adverse effects to human health possibly resulting from consumption of foods containing alkenylbenzenes, especially focusing on the genotoxic compounds, safrole, methyleugenol, and estragole.
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