Evidence map›Paper›PMID 34574216›Full record

ArticleFoods (Basel, Switzerland)2021

Differential Antihypertensive Effects of Oral Doses of Acetylcholine between Spontaneously Hypertensive Rats and Normotensive Rats.

Shohei Yamaguchi, Kento Matsumoto, Wenhao Wang, Kozo Nakamura

Open access · goldAbstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Animal models of hypertension and concurrent organs injury.Animal models and experimental medicine · 2025
    Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Shohei YamaguchiDepartment of Science and Technology, Graduate School of Medicine, Science and Technology, Shinshu University, 8304, Minamiminowa, Nagano 399-4598, Japan.
Kento MatsumotoItoen Co., Ltd., 21, Mekami, Makinohara, Shizuoka 421-0516, Japan.
Wenhao WangDepartment of Science and Technology, Graduate School of Medicine, Science and Technology, Shinshu University, 8304, Minamiminowa, Nagano 399-4598, Japan.
Kozo NakamuraDepartment of Science and Technology, Graduate School of Medicine, Science and Technology, Shinshu University, 8304, Minamiminowa, Nagano 399-4598, Japan.
Shinshu University · JPItochu (Japan) · JP

Funding

Bio-oriented Technology Research Advancement Institution 16932813Japan Society for the Promotion of Science JP18K05515
6 · The paper itself

Abstract

Acetylcholine (ACh) is a novel antihypertensive food component. Here, we demonstrate the differential effects of oral ACh on high and normal blood pressure in rats. Spontaneously hypertensive rats (SHRs) and Wistar-Kyoto (WKY) rats were administered ACh orally. The blood pressure and heart rate of SHRs were significantly lowered with ACh doses of 10

Indexed as

acetylcholineblood pressurefunctional foodspontaneously hypertensive ratsWistar–Kyoto rats

Identifiers

PMID34574216
PMCPMC8469729
OpenAlexW3196320414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.