Evidence map›Paper›PMID 34574031›Full record

ArticleDiagnostics (Basel, Switzerland)2021

The Reproducibility of Deep Learning-Based Segmentation of the Prostate Gland and Zones on T2-Weighted MR Images.

Mohammed R S Sunoqrot, Kirsten M Selnæs, Elise Sandsmark, Sverre Langørgen, Helena Bertilsson, Tone F Bathen, Mattijs Elschot

Abstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mohammed R S SunoqrotDepartment of Circulation and Medical Imaging, NTNU-Norwegian University of Science and Technology, 7030 Trondheim, Norway.ORCID 0000-0001-9239-1683
Kirsten M SelnæsDepartment of Circulation and Medical Imaging, NTNU-Norwegian University of Science and Technology, 7030 Trondheim, Norway.
Elise SandsmarkDepartment of Radiology and Nuclear Medicine, St. Olavs Hospital, Trondheim University Hospital, 7030 Trondheim, Norway.ORCID 0000-0002-2175-8027
Sverre LangørgenDepartment of Radiology and Nuclear Medicine, St. Olavs Hospital, Trondheim University Hospital, 7030 Trondheim, Norway.
Helena BertilssonDepartment of Cancer Research and Molecular Medicine, NTNU-Norwegian University of Science and Technology, 7030 Trondheim, Norway.
Tone F BathenDepartment of Circulation and Medical Imaging, NTNU-Norwegian University of Science and Technology, 7030 Trondheim, Norway.ORCID 0000-0002-8582-6965
Mattijs ElschotDepartment of Circulation and Medical Imaging, NTNU-Norwegian University of Science and Technology, 7030 Trondheim, Norway.

Funding

Norges Forskningsråd 295013Norwegian University of Science and Technology (NTNU) Biotechnology 81770928The liaison committee between the Central Norway Regional Health Authority and Central Norway Regional Health Authority 17/38297
6 · The paper itself

Abstract

Volume of interest segmentation is an essential step in computer-aided detection and diagnosis (CAD) systems. Deep learning (DL)-based methods provide good performance for prostate segmentation, but little is known about the reproducibility of these methods. In this work, an in-house collected dataset from 244 patients was used to investigate the intra-patient reproducibility of 14 shape features for DL-based segmentation methods of the whole prostate gland (WP), peripheral zone (PZ), and the remaining prostate zones (non-PZ) on T2-weighted (T2W) magnetic resonance (MR) images compared to manual segmentations. The DL-based segmentation was performed using three different convolutional neural networks (CNNs): V-Net, nnU-Net-2D, and nnU-Net-3D. The two-way random, single score intra-class correlation coefficient (ICC) was used to measure the inter-scan reproducibility of each feature for each CNN and the manual segmentation. We found that the reproducibility of the investigated methods is comparable to manual for all CNNs (14/14 features), except for V-Net in PZ (7/14 features). The ICC score for segmentation volume was found to be 0.888, 0.607, 0.819, and 0.903 in PZ; 0.988, 0.967, 0.986, and 0.983 in non-PZ; 0.982, 0.975, 0.973, and 0.984 in WP for manual, V-Net, nnU-Net-2D, and nnU-Net-3D, respectively. The results of this work show the feasibility of embedding DL-based segmentation in CAD systems, based on multiple T2W MR scans of the prostate, which is an important step towards the clinical implementation.

Indexed as

computer-aided diagnosisdeep learningMRIprostatesegmentation

Identifiers

PMID34574031
PMCPMC8471645

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.