Evidence map›Paper›PMID 34574027›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Radiomics and Machine Learning Can Differentiate Transient Osteoporosis from Avascular Necrosis of the Hip.

Michail E Klontzas, Georgios C Manikis, Katerina Nikiforaki, Evangelia E Vassalou, Konstantinos Spanakis, Ioannis Stathis, George A Kakkos, Nikolas Matthaiou, Aristeidis H Zibis, Kostas Marias and 1 more

Abstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  5. Multi-Spectral MRI-Based Radiomic Features Can Classify Femoral Loosening in Patients With Total Hip Arthroplasty.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michail E KlontzasDepartment of Medical Imaging, University Hospital of Heraklion, 71110 Heraklion, Crete, Greece.ORCID 0000-0003-2731-933X
Georgios C ManikisComputational BioMedicine Laboratory, Institute of Computer Science, Foundation for Research and Technology (FORTH), 70013 Heraklion, Crete, Greece.
Katerina NikiforakiComputational BioMedicine Laboratory, Institute of Computer Science, Foundation for Research and Technology (FORTH), 70013 Heraklion, Crete, Greece.
Evangelia E VassalouDepartment of Medical Imaging, University Hospital of Heraklion, 71110 Heraklion, Crete, Greece.
Konstantinos SpanakisDepartment of Medical Imaging, University Hospital of Heraklion, 71110 Heraklion, Crete, Greece.
Ioannis StathisDepartment of Medical Imaging, University Hospital of Heraklion, 71110 Heraklion, Crete, Greece.
George A KakkosDepartment of Medical Imaging, University Hospital of Heraklion, 71110 Heraklion, Crete, Greece.
Nikolas MatthaiouDepartment of Medical Imaging, University Hospital of Heraklion, 71110 Heraklion, Crete, Greece.
Aristeidis H ZibisDepartment of Anatomy, Medical School, University of Thessaly, 41334 Larissa, Greece.ORCID 0000-0001-7122-4317
Kostas MariasComputational BioMedicine Laboratory, Institute of Computer Science, Foundation for Research and Technology (FORTH), 70013 Heraklion, Crete, Greece.ORCID 0000-0003-3783-5223
Apostolos H KarantanasDepartment of Medical Imaging, University Hospital of Heraklion, 71110 Heraklion, Crete, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Differentiation between transient osteoporosis (TOH) and avascular necrosis (AVN) of the hip is a longstanding challenge in musculoskeletal radiology. The purpose of this study was to utilize MRI-based radiomics and machine learning (ML) for accurate differentiation between the two entities. A total of 109 hips with TOH and 104 hips with AVN were retrospectively included. Femoral heads and necks with segmented radiomics features were extracted. Three ML classifiers (XGboost, CatBoost and SVM) using 38 relevant radiomics features were trained on 70% and validated on 30% of the dataset. ML performance was compared to two musculoskeletal radiologists, a general radiologist and two radiology residents. XGboost achieved the best performance with an area under the curve (AUC) of 93.7% (95% CI from 87.7 to 99.8%) among ML models. MSK radiologists achieved an AUC of 90.6% (95% CI from 86.7% to 94.5%) and 88.3% (95% CI from 84% to 92.7%), respectively, similar to residents. The general radiologist achieved an AUC of 84.5% (95% CI from 80% to 89%), significantly lower than of XGboost (

Indexed as

artificial intelligenceavascular necrosis of bonehipmachine learningosteoporosisradiomicstransient osteoporosisXGboost

Identifiers

PMID34574027
PMCPMC8468167

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.