ArticleDiagnostics (Basel, Switzerland)2021
Acute Radiation Dermatitis Evaluation with Reflectance Confocal Microscopy: A Prospective Study.
Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 13 citations in OpenAlex.
- Artificial intelligence-based automated grading and severity prediction of radiation dermatitis: a review.Radiation oncology (London, England) · 2025Review
- Individualized 3D printing for skin cancer brachytherapy: Development, implementation, clinical applications, and treatment assessment.Journal of contemporary brachytherapy · 2024Article
- Dermoscopy of acute radiation-induced dermatitis in patients with head and neck cancers treated with radiotherapy.Scientific reports · 2023Article
- Development and performance validation of a low-cost algorithms-based hyperspectral imaging system for radiodermatitis assessment.Biomedical optics express · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring radiotherapy (RT), most breast cancer patients experience ionizing radiation (IR)-induced skin injury-acute radiation dermatitis (ARD). The severity of ARD is determined by a physician according to CTCAE or RTOG scales, which are subjective. Reflectance confocal microscopy (RCM) is a noninvasive skin imaging technique offering cellular resolution. Digital dermoscopy (DD) performed in conjugation with RCM can provide more information regarding skin toxicity. The purpose of this study is to create an RCM and DD features-based ARD assessment scale, to assess the association with CTCAE scale and possible predictive value.
methodsOne hundred and three breast cancer patients during RT were recruited; every week, clinical symptoms of ARD (CTCAE scale) were evaluated and RCM, together with digital dermoscopy (DD), was performed.
resultsAccording to RCM; after 2 RT weeks, exocytosis and/or spongiosis were present in 94% of patients; after 3 weeks, mild contrast cells (MMCs) were detected in 45%; disarrayed epidermis (DE) was present in 66% of patients after 4 weeks and in 93% after 5 weeks; abnormal dermal papillae (ADP) were present in 68% of patients after 5 weeks. The coefficients of RCM features (RCM
conclusionsRCM features of irradiated skin appear earlier than clinical symptoms, have a characteristic course, and allow the severity of ARD to be predicted.
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