ArticleProceedings of the National Academy of Sciences of the United States of America1986
Molecular cloning of cDNA for the nuclear ribonucleoprotein particle C proteins: a conserved gene family.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- Positive Feedback Loop of Histone Lactylation-Driven HNRNPC Promotes Autophagy to Confer Pancreatic Ductal Adenocarcinoma Gemcitabine Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- RNA-binding proteins in disease etiology: fragile X syndrome and spinal muscular atrophy.RNA (New York, N.Y.) · 2025Review
- The Ebola virus VP24 protein prevents hnRNP C1/C2 binding to karyopherin α1 and partially alters its nuclear import.The Journal of infectious diseases · 2011Article
- Hormone response element binding proteins: novel regulators of vitamin D and estrogen signaling.Steroids · 2011Review
- Inferring alternative splicing patterns in mouse from a full-length cDNA library and microarray data.Genome research · 2002Article
- hnRNP C increases amyloid precursor protein (APP) production by stabilizing APP mRNA.Nucleic acids research · 1998Article
- Growth-dependent and growth-independent translation of messengers for heterogeneous nuclear ribonucleoproteins.Nucleic acids research · 1997Article
- Recognition of subsets of the mammalian A/B-type core heterogeneous nuclear ribonucleoprotein polypeptides by novel autoantibodies.The Biochemical journal · 1996Article
- The C-protein tetramer binds 230 to 240 nucleotides of pre-mRNA and nucleates the assembly of 40S heterogeneous nuclear ribonucleoprotein particles.Molecular and cellular biology · 1994Article
- PUB1: a major yeast poly(A)+ RNA-binding protein.Molecular and cellular biology · 1993Article
- Cell cycle-regulated phosphorylation of the pre-mRNA-binding (heterogeneous nuclear ribonucleoprotein) C proteins.Molecular and cellular biology · 1993Article
- Three new members of the RNP protein family in Xenopus.Nucleic acids research · 1993Article
- Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box.The EMBO journal · 1992Article
- Characterization of the major hnRNP proteins from Drosophila melanogaster.The Journal of cell biology · 1992Article
- Tobacco nuclear gene for the 31 kd chloroplast ribonucleoprotein: genomic organization, sequence analysis and expression.Nucleic acids research · 1991Article
- Cloning and nucleotide sequence of cDNA for Ki antigen, a highly conserved nuclear protein detected with sera from patients with systemic lupus erythematosus.Clinical and experimental immunology · 1990Article
- Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts.The Journal of cell biology · 1989Article
- Isolation and characterization of a Xenopus laevis C protein cDNA: structure and expression of a heterogeneous nuclear ribonucleoprotein core protein.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
- cDNA cloning of human hnRNP protein A1 reveals the existence of multiple mRNA isoforms.Nucleic acids research · 1988Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The C proteins, C1 and C2, are major constituents of the heterogeneous nuclear RNA (hnRNA) ribonucleoprotein (hnRNP) complex in vertebrates. C1 and C2 are antigenically related phosphoproteins that are in contact with hnRNA in intact cells and bind to RNA tightly in vitro. A cDNA clone for the C proteins was isolated by immunological screening of a human lambda gt11 expression vector cDNA library with monoclonal antibodies. The lacZ-cDNA fusion protein is recognized by two different anti-C protein monoclonal antibodies. HeLa cell mRNA that was hybrid-selected with the cDNA clone (1.1 kilobases long) was translated in vitro and yielded both the C1 and C2 proteins (41 and 43 kDa, respectively). RNA blot analysis showed strong hybridization to two polyadenylylated transcripts, of about 1.4 kb and 1.9 kb, in human cells. Genomic DNA blot analysis showed multiple hybridizing restriction fragments in human and mouse, and homologous DNA sequences are found across eukaryotes from human to yeast. These findings suggest that the sequences encoding the hnRNP C proteins are members of a conserved gene family and they open the way for detailed molecular and genetic studies of these proteins.
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