Evidence map›Paper›PMID 34573450›Full record

ArticleAnimals : an open access journal from MDPI2021

Preliminary Investigation into a Novel Sustained-Release Formulation of Meloxicam in Sheep (

Christine Plummer, Peter J White, Benjamin Kimble, Merran Govendir, Dominique Van der Saag

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Moxidectin is a candidate for use as anFrontiers in veterinary science · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Christine PlummerFaculty of Science, School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia.
Peter J WhiteFaculty of Science, Sydney School of Veterinary Science, University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0002-9742-4939
Benjamin KimbleFaculty of Science, Sydney School of Veterinary Science, University of Sydney, Sydney, NSW 2006, Australia.
Merran GovendirFaculty of Science, Sydney School of Veterinary Science, University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0003-3595-0500
Dominique Van der SaagFaculty of Science, Sydney School of Veterinary Science, University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0002-1127-7529
The University of Sydney · AU

Funding

Meat and Livestock Australia P.PSH.0818
6 · The paper itself

Abstract

This study is a preliminary investigation describing the pharmacokinetic profile of a novel subcutaneous sustained-release meloxicam formulation (SRMF) in sheep. Six merino ewe hoggets (41.5 ± 4.6 kg) were treated with a novel subcutaneous SRMF at 2 mg/kg bodyweight (BW). Blood samples were collected at t = 0, 2, 4, 6, 8, 10, 12, 24, 48, 96, 144, 168, 192, and 336 h following treatment, and interstitial (ISF) fluid samples were collected at periods of 8 to 12 h, 12 to 24 h, 24 to 48 h, 48 to 52 h, and 92 to 96 h following treatment. High-pressure liquid chromatography (HPLC) analysis with ultraviolet detection was utilised to determine the concentration of meloxicam in plasma and ISF. The SRMF exhibited the following mean (±SD) pharmacokinetic indices: C

Indexed as

meloxicampharmacokineticssheep

Identifiers

PMID34573450
PMCPMC8466480
OpenAlexW3194411486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.