Evidence map›Paper›PMID 34573427›Full record

ArticleGenes2021

RANTES 59029A/G Polymorphisms Associated with Diabetic Compilations in Korean Patients with Type 2 Diabetes for over 15 Years.

Dong-Hwa Lee, Eu-Jeong Ku, Tae-Keun Oh, Hyun-Jeong Jeon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Evidence from genetic studies among rs2107538 variant in theSaudi journal of biological sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Dong-Hwa LeeDepartment of Internal Medicine, Chungbuk National University Hospital, Cheongju 28644, Korea.ORCID 0000-0002-1552-3205
Eu-Jeong KuDepartment of Internal Medicine, Chungbuk National University Hospital, Cheongju 28644, Korea.
Tae-Keun OhDepartment of Internal Medicine, Chungbuk National University Hospital, Cheongju 28644, Korea.
Hyun-Jeong JeonDepartment of Internal Medicine, Chungbuk National University Hospital, Cheongju 28644, Korea.
Chungbuk National University Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPolymorphisms in the RANTES gene are known to be associated with several diseases related to insulin resistance. In this study, we investigated the association between RANTES 59029A/G polymorphisms and the prevalence of diabetic complications relative to obesity in Korean patients who had type 2 diabetes (T2D) for over 15 years.

methodsA single-center, retrospective case-control study was performed. We included 271 patients with a duration of diabetes greater than 15 years. Polymerase chain reaction-restriction fragment length polymorphism was used to analyze RANTES polymorphisms, identifying genotypes as GG, AG, or AA. Obesity was defined using the body mass index with a cutoff value of 25 kg/m

resultsThe duration of T2D and hemoglobin A1c values at enrollment were 24.4 ± 5.0 years and 7.8 ± 1.6%, respectively, in the non-obese group, and 25.4 ± 6.1 years and 7.7 ± 1.7%, respectively, in the obese group. The prevalence of microvascular complications was significantly higher in the obese group compared with that in the non-obese group (83.5% vs. 72.0%,

conclusionsThe A allele of the RANTES gene is associated with obesity and may affect diabetic microvascular complications in patients with T2D for over 15 years.

Indexed as

Polymorphism, GeneticAgedAsian PeopleBody Mass IndexCase-Control StudiesChemokine CCL5Diabetes ComplicationsDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedObesityPolymorphism, Restriction Fragment LengthRetrospective StudiesCCL5 protein, humanChemokine CCL5CCL5diabetic complicationsRANTESsingle nucleotide polymorphismtype 2 diabetes mellitus

Identifiers

PMID34573427
PMCPMC8468929
OpenAlexW3200197281

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.