Evidence map›Paper›PMID 34573372›Full record

ReviewGenes2021

The Role of the Rad55-Rad57 Complex in DNA Repair.

Upasana Roy, Eric C Greene

Open access · goldAbstract readReview
In one paragraph

Review in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Mechanisms That Govern Recombinase Fidelity Control During Eukaryotic Homologous Recombination.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  2. International journal of oncology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Upasana RoyDepartment of Biochemistry & Molecular Biophysics, Columbia University, New York, NY 10032, USA.
Eric C GreeneDepartment of Biochemistry & Molecular Biophysics, Columbia University, New York, NY 10032, USA.
Columbia University · US

Funding

Protein purification instrumentation in support of single molecule studies of genome integrityR35GM118026 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GREENE, ERIC C · 2016 to 2025
$5.7M
Helicase regulation during homologous recombinationR01CA236606 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Eric C Greene · 2019 to 2026
$2.6M
Defining the contributions of BRCA1, BRCA2, and RAD52 to genome stabilityR01CA221858 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GREENE, ERIC C · 2020 to 2024
$1.9M
NCI NIH HHS R01 CA221858NCI NIH HHS R01 CA236606NIGMS NIH HHS R35 GM118026
6 · The paper itself

Abstract

Homologous recombination (HR) is a mechanism conserved from bacteria to humans essential for the accurate repair of DNA double-stranded breaks, and maintenance of genome integrity. In eukaryotes, the key DNA transactions in HR are catalyzed by the Rad51 recombinase, assisted by a host of regulatory factors including mediators such as Rad52 and Rad51 paralogs. Rad51 paralogs play a crucial role in regulating proper levels of HR, and mutations in the human counterparts have been associated with diseases such as cancer and Fanconi Anemia. In this review, we focus on the

Indexed as

Homologous RecombinationAdenosine TriphosphatasesDNA-Binding ProteinsDNA RepairDNA Repair EnzymesGene Expression Regulation, FungalMultiprotein ComplexesMutationSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSingle Molecule ImagingAdenosine TriphosphatasesDNA-Binding ProteinsDNA Repair EnzymesMultiprotein ComplexesRAD55 protein, S cerevisiaeRAD57 protein, S cerevisiaeSaccharomyces cerevisiae Proteinshomologous recombinationRad51Rad51 paralogsRad55–Rad57recombination mediators

Identifiers

PMID34573372
PMCPMC8472222
OpenAlexW3197825729

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.