Evidence map›Paper›PMID 34573368›Full record

ArticleGenes2021

Expression and Polymorphism of TSLP/TSLP Receptors as Potential Diagnostic Markers of Colorectal Cancer Progression.

Abdelhabib Semlali, Mikhlid H Almutairi, Abdullah Alamri, Narasimha Reddy Parine, Maha Arafah, Majid A Almadi, Abdulrahman M Aljebreen, Othman Alharbi, Nahla Ali Azzam, Riyadh Almutairi and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. TSLP: contrasting roles in cancer.Frontiers in immunology · 2025
    Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. International journal of general medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Abdelhabib SemlaliGroupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval, 2420 Rue de la Terrasse, Local 1758, Québec, QC G1V 0A6, Canada.ORCID 0000-0002-5797-8304
Mikhlid H AlmutairiZoology Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Abdullah AlamriDepartment of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Narasimha Reddy ParineDepartment of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-0765-9022
Maha ArafahPathology Department, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia.
Majid A AlmadiDivision of Gastroenterology, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia.
Abdulrahman M AljebreenDivision of Gastroenterology, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia.
Othman AlharbiDivision of Gastroenterology, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia.
Nahla Ali AzzamDivision of Gastroenterology, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-2097-289X
Riyadh AlmutairiDepartment of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Mohammad AlanaziDepartment of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Mahmoud RouabhiaGroupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval, 2420 Rue de la Terrasse, Local 1758, Québec, QC G1V 0A6, Canada.ORCID 0000-0003-2205-8281
King Saud University · SAUniversité Laval · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is the third most common malignancy and the fourth leading cause of cancer-related mortality worldwide. Inflammation is considered as a critical driver for CRC development and growth. We investigated the association between polymorphisms/expression levels of thymic stromal lymphopoietin (TSLP) /TSLP receptors and CRC risk in Saudi population. DNA samples were isolated from blood samples from 220 participants. Case subjects were 112 patients diagnosed with CRC, while control subjects were 108 healthy individuals, who were not diagnosed with any type of malignancy. We selected two single nucleotide polymorphisms (SNPs) located in the thymic stromal lymphopoietin gene (

Indexed as

Polymorphism, Single NucleotideAge FactorsBiomarkers, TumorCase-Control StudiesColorectal NeoplasmsCross-Sectional StudiesCytokinesFemaleGene Expression Regulation, NeoplasticHumansInterleukin-7 Receptor alpha SubunitMaleMiddle AgedReceptors, CytokineThymic Stromal LymphopoietinBiomarkers, TumorCRLF2 protein, humanCytokinesIL7R protein, humanInterleukin-7 Receptor alpha SubunitReceptors, CytokineThymic Stromal LymphopoietinTSLP protein, humancolorectal cancerpolymorphismsTSLPTSLPR

Identifiers

PMID34573368
PMCPMC8469613
OpenAlexW3197842459

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.