ArticleGenes2021
The Genetic Architecture of a Congenital Heart Defect Is Related to Its Fitness Cost.
Ehiole Akhirome, Suk D Regmi, Rachel A Magnan, Nelson Ugwu, Yidan Qin, Claire E Schulkey, James M Cheverud, Patrick Y Jay
Abstract read
In one paragraphArticle in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
Ehiole AkhiromeDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Suk D RegmiDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Rachel A MagnanDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Nelson UgwuDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Yidan QinDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Claire E SchulkeyDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
James M CheverudDepartment of Biology, Loyola University Chicago, Chicago, IL 60660, USA.
Patrick Y JayDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Funding
DEVELOPMENTAL CARDIOLOGY AND PULMONARY TRAINING PROGRAMT32HL007873 · NHLBI · WASHINGTON UNIVERSITY · PI MECHAM, ROBERT P. · 1998 to 2012
$3.6MTHE GENETIC ARCHITECTURE OF CONGENITAL HEART DISEASER01HL105857 · NHLBI · WASHINGTON UNIVERSITY · PI JAY, PATRICK Y · 2011 to 2015
$1.9MHigh-resolution Genetic Mapping of Maternal Effects and Epistatic Suppressors of Congenital Heart Disease RiskF30HL136077 · NHLBI · WASHINGTON UNIVERSITY · PI AKHIROME, EHIOLE OGBOMA · 2017 to 2020
$115kNIH HHS F30 HL136077NIH HHS R01 HL105857NIH HHS T32 HL007873
6 · The paper itselfAbstract
In newborns, severe congenital heart defects are rarer than mild ones. This epidemiological relationship between heart defect severity and incidence lacks explanation. Here, an analysis of ~10,000
Indexed as
Genetic FitnessAnimalsAnimals, NewbornDisease Models, AnimalFemaleGenetic LociHeart Septal DefectsHeart Septal Defects, AtrialHeart Septal Defects, VentricularHomeobox Protein Nkx-2.5HumansMaleMiceMice, TransgenicSeverity of Illness IndexHomeobox Protein Nkx-2.5Nkx2-5 protein, mousecongenital heart defectsgenetic epistasismodifier genesquantitative trait loci
Identifiers
PMID34573350
PMCPMC8467714
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