ArticleGenes2021
Chromosome-Level Genome Assemblies Expand Capabilities of Genomics for Conservation Biology.
Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Chromosome-level genome assembly of the common tenrec, Tenrec ecaudatus (Schreber, 1778), a new model for early placental mammal evolution.BMC genomics · 2026Article
- Comparative Genomics and Phylogenomics of the Mustelinae Lineage (Mustelidae, Carnivora).Genome biology and evolution · 2026Article
- Genomics of Sable (Martes zibellina) × Pine Marten (Martes martes) Hybridization.Genome biology and evolution · 2026Article
- First Chromosome-level Genome Assembly and Annotation of an Endangered Freshwater Stingray (Fontitrygon garouaensis) from Africa.Scientific data · 2026Article
- Chromosome-level genome assembly and transcriptome analysis of the Ural owl, Strix uralensis Pallas, 1771.The Journal of heredity · 2026Article
- Leveraging Synteny to Generate Reference Genomes for Conservation: Assembling the Genomes of Hector's and Māui Dolphins.Molecular ecology resources · 2025Article
- Resilience of Portulaca plants to environmental stresses and the economic potential of their bioactive compounds.Planta · 2025Review
- Chromosome-level genome assembly of a critically endangered species Leuciscus chuanchicus.Scientific data · 2025Article
- The telomere-to-telomere gap-free reference genome and taxonomic reassessment of Siniperca roulei.GigaScience · 2025Article
- Genetic diversity of Anadara tuberculosa in two localities of the Colombian Pacific Coast.Scientific reports · 2024Article
- Chromosome-length genome assembly and karyotype of the endangered black-footed ferret (Mustela nigripes).The Journal of heredity · 2023Article
- Chromosome-level assembly of the Rangifer tarandus genome and validation of cervid and bovid evolution insights.BMC genomics · 2023Article
- Chromosome-Length Assembly of the Baikal Seal (Genes · 2023Article
- Whole genome analysis of clouded leopard species reveals an ancient divergence and distinct demographic histories.iScience · 2022Article
- A Chromosome-Length Reference Genome for the Endangered Pacific Pocket Mouse Reveals Recent Inbreeding in a Historically Large Population.Genome biology and evolution · 2022Article
- Genomics of Adaptation and Speciation.Genes · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome assemblies are in the process of becoming an increasingly important tool for understanding genetic diversity in threatened species. Unfortunately, due to limited budgets typical for the area of conservation biology, genome assemblies of threatened species, when available, tend to be highly fragmented, represented by tens of thousands of scaffolds not assigned to chromosomal locations. The recent advent of high-throughput chromosome conformation capture (Hi-C) enables more contiguous assemblies containing scaffolds spanning the length of entire chromosomes for little additional cost. These inexpensive contiguous assemblies can be generated using Hi-C scaffolding of existing short-read draft assemblies, where N50 of the draft contigs is larger than 0.1% of the estimated genome size and can greatly improve analyses and facilitate visualization of genome-wide features including distribution of genetic diversity in markers along chromosomes or chromosome-length scaffolds. We compared distribution of genetic diversity along chromosomes of eight mammalian species, including six listed as threatened by IUCN, where both draft genome assemblies and newer chromosome-level assemblies were available. The chromosome-level assemblies showed marked improvement in localization and visualization of genetic diversity, especially where the distribution of low heterozygosity across the genomes of threatened species was not uniform.
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