Evidence map›Paper›PMID 34573308›Full record

ArticleGenes2021

Identification of CSF3R Mutations in B-Lineage Acute Lymphoblastic Leukemia Using Comprehensive Cancer Panel and Next-Generation Sequencing.

Mamoon Rashid, Abdulrahman Alasiri, Mohammad A Al Balwi, Aziza Alkhaldi, Ahmed Alsuhaibani, Abdulrahman Alsultan, Talal Alharbi, Lamya Alomair, Bader Almuzzaini

Open access · goldAbstract read
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Mamoon RashidKing Abdullah International Medical Research Center (KAIMRC), Department of Bionformatics, Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh 11426, Saudi Arabia.
Abdulrahman AlasiriKing Abdullah International Medical Research Center (KAIMRC), Medical Genomics Research Department, Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh 11426, Saudi Arabia.ORCID 0000-0003-1450-2936
Mohammad A Al BalwiKing Abdullah International Medical Research Center (KAIMRC), Medical Genomics Research Department, Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh 11426, Saudi Arabia.ORCID 0000-0003-2910-0390
Aziza AlkhaldiPathology and Laboratory Medicine, King Abdul Aziz Medical City, Ministry of National Guard Health Affairs, King Saud Bin Abdul Aziz University for Health Sciences (KSAU-HS), Riyadh 11426, Saudi Arabia.
Ahmed AlsuhaibaniPathology and Laboratory Medicine, King Abdul Aziz Medical City, Ministry of National Guard Health Affairs, King Saud Bin Abdul Aziz University for Health Sciences (KSAU-HS), Riyadh 11426, Saudi Arabia.
Abdulrahman AlsultanDepartment of Pediatric Hematology/Oncology, King Abdullah Specialist Children's Hospital, Ministry of National Guard Health Affairs, King Saud Bin Abdul Aziz University for Health Sciences (KSAU-HS), Riyadh 11426, Saudi Arabia.
Talal AlharbiDepartment of Pediatric Hematology/Oncology, King Abdullah Specialist Children's Hospital, Ministry of National Guard Health Affairs, King Saud Bin Abdul Aziz University for Health Sciences (KSAU-HS), Riyadh 11426, Saudi Arabia.
Lamya AlomairKing Abdullah International Medical Research Center (KAIMRC), Department of Bionformatics, Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh 11426, Saudi Arabia.
Bader AlmuzzainiKing Abdullah International Medical Research Center (KAIMRC), Medical Genomics Research Department, Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh 11426, Saudi Arabia.ORCID 0000-0003-1176-9037
King Saud bin Abdulaziz University for Health Sciences · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

B-lineage acute lymphocytic leukemia (B-ALL) is characterized by different genetic aberrations at a chromosomal and gene level which are very crucial for diagnosis, prognosis and risk assessment of the disease. However, there is still controversial arguments in regard to disease outcomes in specific genetic abnormalities, e.g., 9p-deletion. Moreover, in absence of cytogenetic abnormalities it is difficult to predict B-ALL progression. Here, we use the advantage of Next-generation sequencing (NGS) technology to study the mutation landscape of 12 patients with B-ALL using Comprehensive Cancer Panel (CCP) which covers the most common mutated cancer genes. Our results describe new mutations in

Indexed as

High-Throughput Nucleotide SequencingMutationPrecursor B-Cell Lymphoblastic Leukemia-LymphomaReceptors, Colony-Stimulating FactorAdolescentAdultChildFemaleHumansMaleMiddle AgedYoung AdultCSF3R protein, humanReceptors, Colony-Stimulating Factoracute lymphoblastic leukemiaB-ALLcancerCSF3Rleukemiamutations

Identifiers

PMID34573308
PMCPMC8470887
OpenAlexW3197484322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.