Evidence map›Paper›PMID 34573301›Full record

ReviewGenes2021

Genetic Markers of Differential Vulnerability to Sleep Loss in Adults.

Courtney E Casale, Namni Goel

Open access · goldAbstract readReview
In one paragraph

Review in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Clock-Sleep Communication.Current molecular medicine · 2025
    Review
  5. Article
  6. Observational
  7. Article
  8. Is Short Sleep Bad for the Brain? Brain Structure and Cognitive Function in Short Sleepers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  9. Article
  10. Review
  11. Sleep loss suicidal ideation: the role of trait extraversion.Frontiers in behavioral neuroscience · 2022
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Courtney E CasaleBiological Rhythms Research Laboratory, Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, 1645 W. Jackson Blvd., Suite 425, Chicago, IL 60612, USA.ORCID 0000-0002-6727-5717
Namni GoelBiological Rhythms Research Laboratory, Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, 1645 W. Jackson Blvd., Suite 425, Chicago, IL 60612, USA.ORCID 0000-0003-2602-1996
Rush University Medical Center · US

Funding

Impact of Daytime vs. Delayed Eating Schedule on Weight and Metabolic Markers Among Obese Persons: An Examination of Circadian MechanismsR01DK117488 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI ALLISON, KELLY C, GOEL, NAMNI · 2017 to 2021
$3.8M
NIH HHS R01DK117488
6 · The paper itself

Abstract

In this review, we discuss reports of genotype-dependent interindividual differences in phenotypic neurobehavioral responses to total sleep deprivation or sleep restriction. We highlight the importance of using the candidate gene approach to further elucidate differential resilience and vulnerability to sleep deprivation in humans, although we acknowledge that other omics techniques and genome-wide association studies can also offer insights into biomarkers of such vulnerability. Specifically, we discuss polymorphisms in adenosinergic genes (

Indexed as

Sleep DeprivationAdultBrain-Derived Neurotrophic FactorCatechol O-MethyltransferaseGenetic MarkersGenome-Wide Association StudyHumansPeriod Circadian ProteinsReceptor, Adenosine A2AReceptors, Dopamine D2SleepBDNF protein, humanBrain-Derived Neurotrophic FactorCatechol O-MethyltransferaseCOMT protein, humanGenetic MarkersPER3 protein, humanPeriod Circadian ProteinsReceptor, Adenosine A2AReceptors, Dopamine D2candidate genescircadian clock genescountermeasuresinterindividual differencesneurobehavioralpolymorphismsresiliencesleep restrictiontotal sleep deprivationvulnerability

Identifiers

PMID34573301
PMCPMC8464868
OpenAlexW3194829161

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.