Evidence map›Paper›PMID 34573263›Full record

ArticleBrain sciences2021

Serum Activin A as Brain Injury Biomarker in the First Three Days of Life. A Prospective Case-Control Longitudinal Study in Human Premature Neonates.

Dimitra Metallinou, Grigorios Karampas, Eleftheria Lazarou, Nikoletta Iacovidou, Panagiota Pervanidou, Katerina Lykeridou, George Mastorakos, Demetrios Rizos

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06893926 recruitingnot on this mapstarted 2024, after this paper: background citation

Evaluating the Utility of S100B Protein Concentration for Diagnosing Fetal Central Nervous System Hypoxia-Ischemia in Children With Late Fetal Growth Retardation: A Prospective Cohort Study

TypeobservationalSponsorInstitute of Mother and Child, Warsaw, PolandRan2024 to 2026Enrolled120Conditionss100b, Hypoxia-Ischemia, Brain, Fetal Growth Restriction (FGR)ArmsPrenatal ultrasound examination with blood flow analysis, Umbilical cord blood gas analysis, Umbilical cord blood S100B protein level, Neonatal transfontanelle ultrasound assessment
NCT06984445 recruitingnot on this mapstarted 2024, after this paper: background citation

Analysis of Cord Blood S100B Protein Levels in Neonates With Fetal Anemia Due to Hemolytic Disease Undergoing Intrauterine Transfusions: A Prospective Cohort Study

TypeobservationalSponsorInstitute of Mother and Child, Warsaw, PolandRan2024 to 2026Enrolled180Conditionss100b, Hypoxia-Ischemia, Brain, Hemolytic Disease of the Fetus and Newborn, Fetal AnemiaArmsCord blood S100B protein level prior to IUT, Umbilical cord blood gas analysis prior to IUT, Fetal blood count evaluation prior to IUT, Cord blood S100B protein concentration at birth, Umbilical cord blood gas analysis at birth
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Dimitra MetallinouDepartment of Midwifery, University of West Attica, Ag. Spyridonos Street, 12243 Egaleo, Greece.ORCID 0000-0003-1788-3818
Grigorios Karampas2nd Department of Obstetrics and Gynecology, Aretaieio University Hospital, 46 Vasilissis Sofias Avenue, 11528 Athens, Greece.ORCID 0000-0001-5897-8958
Eleftheria LazarouDepartment of Obstetrics, Iasis Private Hospital Paphos, 8 Voriou Ipirou Street, 8036 Paphos, Cyprus.
Nikoletta IacovidouNeonatal Department, Aretaieio University Hospital, 46 Vasilissis Sofias Avenue, 11528 Athens, Greece.
Panagiota PervanidouUnit of Developmental and Behavioral Pediatrics, 1st Department of Pediatrics, National and Kapodistrian University of Athens, 5 Mikras Asias Street, 11527 Athens, Greece.
Katerina LykeridouDepartment of Midwifery, University of West Attica, Ag. Spyridonos Street, 12243 Egaleo, Greece.
George MastorakosUnit of Endocrinology, Diabetes Mellitus and Metabolism, Aretaieio University Hospital, 46 Vasilissis Sofias Avenue, 11528 Athens, Greece.
Demetrios RizosHormone Laboratory, Aretaieio University Hospital, 46 Vasilissis Sofias Avenue, 11528 Athens, Greece.ORCID 0000-0003-2143-3377
Aretaeio Hospital · GRUniversity of West Attica · GRNational and Kapodistrian University of Athens · GRPaphos General Hospital · CY

Funding

Special Account for Research Grants 019773/2020
6 · The paper itself

Abstract

Disruption of normal intrauterine brain development is a significant consequence of premature birth and may lead to serious complications, such as neonatal brain injury (NBI). This prospective case-control longitudinal study aimed at determining the levels and prognostic value of serum activin A during the first three days of life in human premature neonates which later developed NBI. It was conducted in a single tertiary hospital and eligible participants were live-born premature (<34 weeks) neonates. Each case (

Indexed as

activin Abiomarkerintraventricular haemorrhageneonatal brain injuryperiventricular leukomalaciapremature neonatesserum

Identifiers

PMID34573263
PMCPMC8468004
OpenAlexW3199073512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.