Evidence map›Paper›PMID 34573259›Full record

ArticleBrain sciences2021

Genotyping and Plasma/Cerebrospinal Fluid Profiling of a Cohort of Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Patients.

Mara Bourbouli, George P Paraskevas, Mihail Rentzos, Lambros Mathioudakis, Vasiliki Zouvelou, Anastasia Bougea, Athanasios Tychalas, Vasilios K Kimiskidis, Vasilios Constantinides, Spiros Zafeiris and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Mara BourbouliNeurogenetics Laboratory, Neurology Department, Medical School, University of Crete, 71003 Heraklion, Greece.
George P Paraskevas1st Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, Eginition Hospital, 11528 Athens, Greece.
Mihail Rentzos1st Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, Eginition Hospital, 11528 Athens, Greece.
Lambros MathioudakisNeurogenetics Laboratory, Neurology Department, Medical School, University of Crete, 71003 Heraklion, Greece.
Vasiliki Zouvelou1st Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, Eginition Hospital, 11528 Athens, Greece.
Anastasia Bougea1st Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, Eginition Hospital, 11528 Athens, Greece.ORCID 0000-0003-3006-8711
Athanasios TychalasDepartment of Neurology, Papageorgiou General Hospital, 56403 Thessaloniki, Greece.ORCID 0000-0002-8457-943X
Vasilios K Kimiskidis1st Department of Neurology, AHEPA Hospital, Aristotle University of Thessaloniki, 54621 Thessaloniki, Greece.
Vasilios Constantinides1st Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, Eginition Hospital, 11528 Athens, Greece.ORCID 0000-0001-7432-5009
Spiros ZafeirisNeurogenetics Laboratory, Neurology Department, Medical School, University of Crete, 71003 Heraklion, Greece.
Minas TzagournissakisNeurogenetics Laboratory, Neurology Department, Medical School, University of Crete, 71003 Heraklion, Greece.
Georgios Papadimas1st Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, Eginition Hospital, 11528 Athens, Greece.
Georgia Karadima1st Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, Eginition Hospital, 11528 Athens, Greece.
Georgios Koutsis1st Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, Eginition Hospital, 11528 Athens, Greece.ORCID 0000-0002-8980-8377
Christos KroupisDepartment of Clinical Biochemistry, Attikon University General Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.ORCID 0000-0002-5876-2599
Chrisoula Kartanou1st Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, Eginition Hospital, 11528 Athens, Greece.
Elisabeth Kapaki1st Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, Eginition Hospital, 11528 Athens, Greece.
Ioannis ZaganasNeurogenetics Laboratory, Neurology Department, Medical School, University of Crete, 71003 Heraklion, Greece.
National and Kapodistrian University of Athens · GRUniversity of Crete · GRAristotle University of Thessaloniki · GRPapageorgiou General Hospital · GR

Funding

Lilian Voudouri Institute NA
6 · The paper itself

Abstract

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are part of the same pathophysiological spectrum and have common genetic and cerebrospinal fluid (CSF) biomarkers. Our aim here was to identify causative gene variants in a cohort of Greek patients with FTD, ALS and FTD-ALS, to measure levels of CSF biomarkers and to investigate genotype-phenotype/CSF biomarker associations. In this cohort of 130 patients (56 FTD, 58 ALS and 16 FTD-ALS), we performed

Indexed as

amyotrophic lateral sclerosisbiomarkersC9orf72frontotemporal dementiageneticsGRNTARDBPVCP

Identifiers

PMID34573259
PMCPMC8472580
OpenAlexW3199268084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.