ReviewBrain sciences2021
Longitudinal Changes in Cognition, Behaviours, and Functional Abilities in the Three Main Variants of Primary Progressive Aphasia: A Literature Review.
Review in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Longitudinal evaluation of common and unique brain-networks in variants of primary progressive aphasia.Alzheimer's research & therapy · 2025Article
- The graded multidimensional geometry of phenotypic variation and progression in neurodegenerative syndromes.Brain : a journal of neurology · 2025Article
- Efficacy of Acetylcholinesterase Inhibitors in the Logopenic Variant of Primary Progressive Aphasia.Dementia and geriatric cognitive disorders · 2025Article
- Rethinking the diagnosis of primary progressive aphasia: current challenges and future directions.Frontiers in aging neuroscience · 2025Article
- The Classification and Language Description of Patients with Primary Progressive Aphasia Using the Mini Linguistic State Examination Test.Geriatrics (Basel, Switzerland) · 2024Article
- Clinicoradiological and neuropathological evaluation of primary progressive aphasia.Journal of neurology, neurosurgery, and psychiatry · 2024Article
- Article
- Rehabilitation Services for Young-Onset Dementia: Examples from High- and Low-Middle-Income Countries.International journal of environmental research and public health · 2024Review
- Primary progressive aphasia: six questions in search of an answer.Journal of neurology · 2024Review
- Symptom-led staging for semantic and non-fluent/agrammatic variants of primary progressive aphasia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Identifying and Diagnosing TDP-43 Neurodegenerative Diseases in Psychiatry.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Review
- Gesture profiles distinguish primary progressive aphasia variants: A preliminary study.Aphasiology · 2024Article
- Unravelling neurotransmitters impairment in primary progressive aphasias.Human brain mapping · 2023Article
- Symptom-led staging for primary progressive aphasia.medRxiv : the preprint server for health sciences · 2023Article
- Gesture profiles distinguish primary progressive aphasia variants.bioRxiv : the preprint server for biology · 2023Article
- Silent Pauses and Speech Indices as Biomarkers for Primary Progressive Aphasia.Medicina (Kaunas, Lithuania) · 2022Article
- Sex influences clinical phenotype in frontotemporal dementia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Advances in Primary Progressive Aphasia.Brain sciences · 2022Article
- Towards a more cognitive evaluation of progressive aphasias?Brain communications · 2022Article
- Primary progressive aphasia and motor neuron disease: A review.Frontiers in aging neuroscience · 2022Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary progressive aphasias (PPAs) are a group of neurodegenerative diseases presenting with insidious and relentless language impairment. Three main PPA variants have been described: the non-fluent/agrammatic variant (nfvPPA), the semantic variant (svPPA), and the logopenic variant (lvPPA). At the time of diagnosis, patients and their families' main question pertains to prognosis and evolution, but very few data exist to support clinicians' claims. The objective of this study was to review the current literature on the longitudinal changes in cognition, behaviours, and functional abilities in the three main PPA variants. A comprehensive review was undertaken via a search on PUBMED and EMBASE. Two authors independently reviewed a total of 65 full-text records for eligibility. A total of 14 group studies and one meta-analysis were included. Among these, eight studies included all three PPA variants. Eight studies were prospective, and the follow-up duration was between one and five years. Overall, svPPA patients showed more behavioural disturbances both at baseline and over the course of the disease. Patients with lvPPA showed a worse cognitive decline, especially in episodic memory, and faster progression to dementia. Finally, patients with nfvPPA showed the most significant losses in language production and functional abilities. Data regarding the prodromal and last stages of PPA are still missing and studies with a longer follow-up observation period are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.