ArticleBrain sciences2021
Systemic Inflammatory Response Index and Futile Recanalization in Patients with Ischemic Stroke Undergoing Endovascular Treatment.
Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
73 citing papers in PubMed, 4 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Systemic inflammation response index as a clinical outcome evaluating tool and prognostic indicator for hospitalized stroke patients: a systematic review and meta-analysis.European journal of medical research · 2023Pooled it
- Neutrophil to lymphocyte ratio predicting poor outcome after aneurysmal subarachnoid hemorrhage: A retrospective study and updated meta-analysis.Frontiers in immunology · 2022Pooled it
- The Neutrophil to Lymphocyte Ratio in Poststroke Infection: A Systematic Review and Meta-Analysis.Disease markers · 2022Pooled it
- Predictive value of neutrophil to lymphocyte ratio for ischemic stroke in patients with atrial fibrillation: A meta-analysis.Frontiers in neurology · 2022Pooled it
- Favorable Systemic Immune-Inflammation Status Enhances the Neuroprotective Effects of Butylphthalide in Ischemic Stroke: A Post Hoc Analysis of BAST Trial.CNS neuroscience & therapeutics · 2026Trial
- Systemic Immune-Inflammatory Markers for Predicting Infarct Volume and Mortality in Patients with Acute Ischemic Stroke: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Clinical prediction model of invalid recanalization after complete reperfusion after thrombectomy in acute ischemic stroke patients: a large retrospective study.Journal of neurointerventional surgery · 2026Article
- Systemic inflammation and endothelial dysfunction influence the risk and severity of hemorrhagic transformation after endovascular treatment for acute ischemic stroke.Frontiers in neurology · 2026Article
- Association of the C-reactive protein-albumin-lymphocyte index with clinical outcomes after mechanical thrombectomy for acute ischemic stroke.Frontiers in aging neuroscience · 2026Article
- Comprehensive immunological profiling of acute ischemic stroke during mechanical thrombectomy: myeloid cell activation and molecular signatures in blood and thrombus.Frontiers in stroke · 2026Article
- Associations of nine composite inflammatory indices with clinical outcomes after mechanical thrombectomy for acute ischemic stroke: a single-center retrospective study.Frontiers in neurology · 2026Article
- Admission systemic inflammatory indices and 6-month functional outcome after endovascular thrombectomy for acute ischemic stroke: an exploratory single-center cohort study.Frontiers in neurology · 2026Article
- Inflammatory Response Indices in Patients with Acute Ischemic Stroke Treated with and Without Reperfusion Therapy.Journal of clinical medicine · 2025Article
- Association between non-traditional lipid parameters and futile recanalization in patients with acute ischemic stroke undergoing mechanical thrombectomy.European journal of medical research · 2025Article
- Association between hyperglycemia and unfavorable outcome in patients with successful thrombectomy for acute ischemic stroke: a single-center study.BMC neurology · 2025Article
- Developing an Explainable Prognostic Model for Acute Ischemic Stroke: Combining Clinical and Inflammatory Biomarkers With Machine Learning.Brain and behavior · 2025Article
- A retrospective observational study on the prognostic role of inflammatory markers in futile recanalization after endovascular treatment for large-vessel stroke.The Journal of international medical research · 2025Observational
- Age-Specific Differences in Inflammatory Biomarkers and Their Impact on Futile Recanalization After Mechanical Thrombectomy: An Inverse Probability Weighting Analysis.European journal of neurology · 2025Observational
- High systemic inflammatory response index (SIRI) is an independent risk factor for poor outcome in IgA nephropathy patients.International urology and nephrology · 2025Article
- Association between the systemic inflammatory response index and acute ischemic stroke in young people.Frontiers in neurology · 2025Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Futile recanalization remains a significant challenge for endovascular treatment (EVT) of acute ischemic stroke (AIS). The inflammatory response that occurs after cerebral infarct plays a central role in stroke pathobiology that can influence the outcome of a recanalization procedure. The aim of this study was to evaluate the relationship between the systemic inflammatory response index (SIRI) and futile recanalization in patients with AIS. We retrospectively identified consecutive patients with ischemic stroke due to proximal arterial occlusion in the anterior circulation, who were treated with EVT and achieved near-complete or complete recanalization. Absolute neutrophil count (ANC), absolute monocyte count (AMC), and absolute lymphocyte count (ALC) were collected from admission blood work to calculate SIRI as ANC × AMC/ALC. The study outcome was futile recanalization, defined as poor functional status [modified Rankin scale (mRS) score ≥ 3] at 3 months despite complete or near-complete recanalization. A total of 184 patients were included. Futile recanalization was observed in 110 (59.8%) patients. Older patients (odds ratio (OR) = 1.07, 95% confidence interval (CI): 1.04-1.10,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.