Evidence map›Paper›PMID 34573150›Full record

ArticleBrain sciences2021

Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome.

Jordan P Harp, Lisa M Koehl, Kathryn L Van Pelt, Christy L Hom, Eric Doran, Elizabeth Head, Ira T Lott, Frederick A Schmitt

Abstract read
In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Adaptive and Maladaptive Behaviours and Their Cognitive Correlates in Aging Adults With Down Syndrome.Journal of applied research in intellectual disabilities : JARID · 2026
    Article
  2. Article
  3. The Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS): A 10-year report.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  4. Cognitive outcome measures for tracking Alzheimer's disease in Down syndrome.International review of research in developmental disabilities · 2022
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jordan P HarpDepartment of Neurology, University of Kentucky, Lexington, KY 40506, USA.ORCID 0000-0003-2089-0883
Lisa M KoehlDepartment of Neurology, University of Kentucky, Lexington, KY 40506, USA.
Kathryn L Van PeltSanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA.
Christy L HomDepartment of Psychiatry and Human Behavior, University of California, Irvine, CA 92697, USA.
Eric DoranDepartment of Pediatrics, School of Medicine, University of California, Irvine, CA 92697, USA.
Elizabeth HeadDepartment of Pathology & Laboratory Medicine, University of California, Irvine, CA 92697, USA.
Ira T LottDepartments of Neurology and Pediatrics, University of California, Irvine, CA 92697, USA.
Frederick A SchmittDepartment of Neurology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA.ORCID 0000-0003-4315-2488

Funding

Project 3: Biomarkers for DS Clinical TrialsU19AG068054 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COHEN, ANN D. · 2020 to 2025
$103.7M
UC Irvine Alzheimer's Disease Research Center Induced Pluripotent Stem Cell CoreP50AG016573 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAFERLA, FRANK M · 2000 to 2019
$37.0M
University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Elizabeth Head · 2020 to 2026
$27.9M
Biomarkers of Alzheimer's Disease in Adults with Down SyndromeU01AG051412 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LOTT, IRA T., SCHUPF, NICOLE · 2015 to 2019
$26.3M
University of Kentucky Alzheimer's Disease Research CenterP30AG072946 · NIA · UNIVERSITY OF KENTUCKY · PI LINDA J VAN ELDIK · 2021 to 2026
$23.5M
University of Kentucky Alzheimer's Disease Core Center - Biomarker CoreP30AG028383 · NIA · UNIVERSITY OF KENTUCKY · PI GOLD, BRIAN TIMOTHY, VAN ELDIK, LINDA J · 2006 to 2020
$23.3M
INSTITUTE FOR CLINICAL AND TRANSLATIONAL SCIENCEUL1RR031985 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M · 2010 to 2011
$7.2M
Aging of Frontal Structure and Function in Down Syndrome and DementiaR01HD064993 · NICHD · UNIVERSITY OF KENTUCKY · PI HEAD, ELIZABETH, SCHMITT, FREDERICK · 2009 to 2019
$5.1M
Training in Translational Research in Alzheimer's and Related Dementias (TRIAD)T32AG057461 · NIA · UNIVERSITY OF KENTUCKY · PI MURPHY, MICHAEL PAUL, VAN ELDIK, LINDA J · 2017 to 2021
$2.1M
Alzheimer's Disease in Down Syndrome: Antioxidant TrialR01AG021912 · NIA · UNIVERSITY OF CALIFORNIA IRVINE · PI LOTT, IRA T · 2003 to 2005
$1.1M
National Institute of Child Health and Human Development HDR01064993NCATS NIH HHS UL1 TR001414NCRR NIH HHS UL1 RR031985NIA NIH HHS 1T32AG057461NIA NIH HHS AG-21912NIA NIH HHS P30 AG028383NIA NIH HHS P30AG066519NIA NIH HHS P30 AG072946NIA NIH HHS P50-16573NIA NIH HHS U01 AG051412NIA NIH HHS U19 AG068054
6 · The paper itself

Abstract

Primary care integration of Down syndrome (DS)-specific dementia screening is strongly advised. The current study employed principal components analysis (PCA) and classification and regression tree (CART) analyses to identify an abbreviated battery for dementia classification. Scale- and subscale-level scores from 141 participants (no dementia

Indexed as

cognitiondementiaDown syndromefunctional independenceneuropsychological assessmentprimary carescreening

Identifiers

PMID34573150
PMCPMC8468129

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.