Evidence map›Paper›PMID 34573133›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Alpha-Ketoglutarate: A Potential Inner Mitochondrial and Cytosolic Protector against Peroxynitrite and Peroxynitrite-Induced Nitration?

Joachim Greilberger, Michaela Greilberger, Reinhold Wintersteiger, Klaus Zangger, Ralf Herwig

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. The research progress of α-ketoglutarate in osteoarthritis.Biochemistry and biophysics reports · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Joachim GreilbergerOtto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Division of Physiological Chemistry, Medical University of Graz, 8010 Graz, Austria.ORCID 0000-0001-6676-0908
Michaela GreilbergerSchwarzl Medical Center, Institute of Scientific Laboratory, 8301 Graz, Austria.
Reinhold WintersteigerDepartment of Pharmaceutical Chemistry, Institute of Pharmaceutical Sciences, University of Graz, 8010 Graz, Austria.
Klaus ZanggerInstitute of Chemistry, Organic and Bioorganic Chemistry, University of Graz, 8010 Graz, Austria.
Ralf HerwigGerman Medical Center, Department of Urology Surgery, Dubai 665664, United Arab Emirates.ORCID 0000-0002-9879-6742
University of Graz · ATDubai Medical College · AEMedical University of Graz · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The generation of peroxynitrite (ONOO

Indexed as

alpha-ketoglutarate (αKG)peroxynitrite (ONOO−)reactive oxygen and nitrogen species (RONS)

Identifiers

PMID34573133
PMCPMC8468307
OpenAlexW3199006471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.