Evidence map›Paper›PMID 34573084›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Standardized Edible Bird's Nest Extract Prevents UVB Irradiation-Mediated Oxidative Stress and Photoaging in the Skin.

Ok-Kyung Kim, Dakyung Kim, Minhee Lee, Seong-Hoo Park, Wakana Yamada, Sangwon Eun, Jeongmin Lee

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Ok-Kyung KimDivision of Food and Nutrition and Human Ecology Research Institute, Chonnam National University, Gwangju 61186, Korea.ORCID 0000-0002-8338-2571
Dakyung KimDepartment of Medical Nutrition, Kyung Hee University, Yongin 17104, Korea.ORCID 0000-0001-9619-5081
Minhee LeeDepartment of Medical Nutrition, Kyung Hee University, Yongin 17104, Korea.ORCID 0000-0002-8820-4395
Seong-Hoo ParkDepartment of Medical Nutrition, Kyung Hee University, Yongin 17104, Korea.ORCID 0000-0001-8808-6328
Wakana YamadaOryza Oil & Fat Chemical Co., Ltd., Ichinomiya 493-8001, Japan.
Sangwon EunR&D Division, Daehan Chemtech Co. Ltd., Seoul 01811, Korea.
Jeongmin LeeDepartment of Medical Nutrition, Kyung Hee University, Yongin 17104, Korea.
Kyung Hee University Medical Center · KRChonnam National University · KRKyung Hee University · KROryza (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated whether standardized edible bird's nest extract (BNE-PK) can prevent ultraviolet B (UVB) irradiation-mediated oxidative stress and photoaging in the skin using in vitro and in vivo models. BNE-PK increased skin hydration by hyaluronic acid synthesis and activation of ceramide synthase in UVB-irradiated hairless mice and HaCaT cells. Furthermore, BNE-PK suppressed melanogenesis by down-regulation of the cAMP/PKA/CREB/MITF/TRP-1/TRP-2/tyrosinase pathway in UVB-irradiated hairless mice and 3-isobutyl-1-methylxanthine (IBMX)-treated B16F10 cells. In UVB-irradiated hairless mice, BNE-PK attenuated the wrinkle formation-related JNK/c-FOS/c-Jun/MMP pathway and activated the TGF-βRI/SMAD3/pro-collagen type I pathway during UVB-mediated oxidative stress. Based on these findings, our data suggest that BNE-PK may potentially be used for the development of effective natural anti-photoaging functional foods for skin health.

Indexed as

edible bird’s nestoxidative stressskin photoagingultraviolet B

Identifiers

PMID34573084
PMCPMC8470287
OpenAlexW3201117372

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.