Evidence map›Paper›PMID 34573062›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Ergosta-7,9(11),22-trien-3β-ol Attenuates Inflammatory Responses via Inhibiting MAPK/AP-1 Induced IL-6/JAK/STAT Pathways and Activating Nrf2/HO-1 Signaling in LPS-Stimulated Macrophage-like Cells.

Yi-Ping Huang, Dar-Ren Chen, Wen-Jen Lin, Yu-Hsien Lin, Jiann-Yeu Chen, Yueh-Hsiung Kuo, Jing-Gung Chung, Te-Chun Hsia, Wen-Tsong Hsieh

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Immunopharmacological Insights intoCurrent pharmaceutical design · 2025
    Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Immunomodulatory Effects of (Pharmaceuticals (Basel, Switzerland) · 2022
    Article
  12. Reviving the mutual impact of SARS-COV-2 and obesity on patients: From morbidity to mortality.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Yi-Ping HuangDepartment of Physiology, China Medical University, Taichung 404333, Taiwan.
Dar-Ren ChenComprehensive Breast Cancer Center, Changhua Christian Hospital, Changhua 50006, Taiwan.
Wen-Jen LinGraduate Institute of Biomedical Science, China Medical University, Taichung 404333, Taiwan.ORCID 0000-0001-9568-9178
Yu-Hsien LinSchool of Pharmacy, China Medical University, Taichung 406040, Taiwan.
Jiann-Yeu ChenCenter for Advanced Science and Technology, National Chung Hsing University, Taichung 40227, Taiwan.
Yueh-Hsiung KuoDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404333, Taiwan.ORCID 0000-0001-5935-6755
Jing-Gung ChungDepartment of Biological Science and Technology, China Medical University, Taichung 404333, Taiwan.ORCID 0000-0002-7303-2287
Te-Chun HsiaDepartment of Respiratory Therapy, China Medical University, Taichung 404333, Taiwan.
Wen-Tsong HsiehDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404333, Taiwan.ORCID 0000-0002-2330-8898
China Medical University · TWAsia University · TWChanghua Christian Hospital · TWNational Chung Hsing University · TW

Funding

Drug Development Center & Chinese Medicine Research Center, China Medical University from the Featured Areas Research Center Program within the Higher Education Sprout Project framework by the Ministry of Education (MOE) in Taiwan CMRC-CHM-4Medical Research Core Facilities, Office of Research & Development at China Medical University CMU107-ASIA-24 & CMU103-ASIA-21
6 · The paper itself

Abstract

Chronic inflammation induces autoimmune disorders and chronic diseases. Several natural products activate nuclear factor erythroid 2-related factor 2 (Nrf2) signaling, attenuating inflammatory responses. Ergosta-7,9(11),22-trien-3β-ol (EK100) isolated from

Indexed as

anti-inflammatory responseatomic force microscopy (AFM)Cordyceps militarisErgosta-7,9(11),22-trien-3β-ol (EK100)IL-6/JAK/STAT signaling pathwaysMAPK/AP-1 signaling pathwaysNrf2/ HO-1 signaling pathway

Identifiers

PMID34573062
PMCPMC8464970
OpenAlexW3197094808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.