Evidence map›Paper›PMID 34573009›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Cellular Redox Homeostasis.

Kristell Le Gal, Edward E Schmidt, Volkan I Sayin

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 1 synthesis or guideline pooled it, 135 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Pharmaceuticals (Basel, Switzerland) · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. ZnJournal of nanobiotechnology · 2026
    Article
  13. Article
  14. Article
  15. Review
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  17. Article
  18. Article
  19. Review
  20. Review

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 3 countries.

Kristell Le GalInstitute of Clinical Sciences, Department of Surgery, Sahlgrenska Center for Cancer Research, University of Gothenburg, 405 30 Gothenburg, Sweden.
Edward E SchmidtMicrobiology & Cell Biology, Montana State University, Bozeman, MT 59718, USA.
Volkan I SayinInstitute of Clinical Sciences, Department of Surgery, Sahlgrenska Center for Cancer Research, University of Gothenburg, 405 30 Gothenburg, Sweden.ORCID 0000-0002-5225-8260
University of Gothenburg · SEMontana State University · US

Funding

Metabolic basis of the NADPH-independent disulfide reductase system in mouse liverR01DK123738 · NIDDK · MONTANA STATE UNIVERSITY - BOZEMAN · PI DENICOLA, GINA MARIE, SCHMIDT, EDWARD E · 2020 to 2022
$1.3M
Hepatocyte-targeted somatic-cell genetic complementation in miceR21OD026444 · OD · MONTANA STATE UNIVERSITY - BOZEMAN · PI SCHMIDT, EDWARD E · 2019 to 2020
$396k
NIDDK NIH HHS R01 DK123738NIH HHS R21 OD026444
6 · The paper itself

Abstract

Cellular redox homeostasis is an essential and dynamic process that ensures the balance between reducing and oxidizing reactions within cells and regulates a plethora of biological responses and events. The study of these biochemical reactions has proven difficult over time, but recent technical and methodological developments have contributed to the rapid growth of the redox field and to our understanding of its importance in biology. The aim of this short review is to give the reader an overall understanding of redox regulation in the areas of cellular signaling, development, and disease, as well as to introduce some recent discoveries in those fields.

Indexed as

antioxidantsglutathionehomeostasisoxidationredoxreductionROSthioredoxin

Identifiers

PMID34573009
PMCPMC8469889
OpenAlexW3196704680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.